基于丝素蛋白的新型药物递送系统研究进展

Advances in Silk Fibroin-Based Novel Drug Delivery Systems

丝素蛋白是从蚕丝或蜘蛛丝中提取的具有良好机械强度的天然高分子纤维蛋白,具有良好的晶体多态性、生物相容性和生物可降解性、细胞黏附性、易于化学修饰和低免疫原性等特点,基于丝素蛋白的药物递送系统还具有良好的热稳定性、制备温和、提高蛋白质等生物药物稳定性的特点,近年来在小分子药物和生物大分子药物递送方面都受到了广泛关注。本文从丝素蛋白的结构、制备工艺、释药特性等方面综述了其在膜剂、凝胶剂、微球、纳米制剂、微针、脂质体、干粉吸入剂等剂型中的最新研究进展,并对其发展方向进行了总结和展望。

As a natural polymeric fiber protein originated from silk with good mechanical strength,polymorphism,biocompatibility and biodegradability,ease for chemical modification,and low immunogenicity,silk fibroin has attracted more and more attention from bio-pharmaceutical areas in recent years.Recently,silk fibroin has been found to be a promising macromolecular drug delivery carrier that might have additional advantages over PLGA such as high resistance to autoclaved sterilization and the ability to improve protein stability.This paper aims to give an overview of the latest applications of silk fibroin in a variety of new dosage forms such as films,hydrogels,microspheres,nanoparticles,microneedles,liposomes and dry powder inhalations.The unique structure and physicochemical properties,preparation technologies and drug release mechanisms of silk fibroin-based formulations are detailedly discussed here to provide important theoretical references for novel sustained drug delivery system design,with a prospect of its future development towards pharmaceutical applications.