水杨醛缩2-肼咪唑希夫碱的合成、晶体结构及其与DNA作用的光谱研究

Synthesis,Crystal Structure of Salicylaldehyde-Condensed 2-Hydrazinoimidazole Schiff Base and Spectrum Study of Its Interaction with DNA

希夫碱及其金属配合物因具有显著的抗菌、抗癌、抗病毒生物活性,在分析化学、生物化学、光电技术等众多领域中应用广泛。本文利用2-肼咪唑啉溴酸盐和水杨醛反应,得到希夫碱(L),通过X-射线单晶衍射确定L是正交晶系,Aba2点群,并利用紫外-可见吸收光谱和荧光光谱研究L与ct-DNA的相互作用方式,结果表明L与ct-DNA有微弱的插入作用。

Schiff bases and their metal complexes are widely used in analytical chemistry,biochemistry,photoelectric technology and many other fields because of their remarkable antibacterial,anticancer and antiviral biological activities.In this paper,Schiff base(L)was obtained by the reaction of 2-hydrazinimidazole and salicylaldehyde.The crystal of L was determined to be orthorhombic by X-ray single crystal diffraction.The interaction between L and ct-DNA was studied by UV-Vis absorption spectrum and fluorescence spectrum.The results showed that L had weak intercalation with ct-DNA.