头颈部鳞状细胞癌差异表达基因分析

Differentially Expressed Gene Analysis for HNSCC

头颈部鳞状细胞癌是最常见的恶性肿瘤之一,病死率很高。本文从美国癌症基因组图谱(TCGA)数据库中下载头颈鳞癌的基因表达数据和临床数据,筛选HPV阳性和HPV阴性的头颈鳞癌组织之间与患者生存相关的差异表达基因,然后参考COSMIC和TSGene2.0数据库中的原癌基因和抑癌基因信息,挑选出可能使HPV阳性头颈鳞癌患者的预后优于HPV阴性头颈鳞癌患者的预后的基因。根据生存分析找到MAP4K1、IKZF3、MZB1、TSPAN32、CCND1、CDK6和WT1与HPV相关的头颈鳞癌的预后相关,为头颈鳞癌的临床诊断和治疗提供潜在的靶点。

Head and neck squamous cell carcinoma(HNSCC)is one of most common malignant tumors with high mortality.The gene expression data and clinical data of HNSCC were downloaded from The Cancer Genome Atlas(TCGA)in this paper,and then the survival related differentially expressed genes between HPV-positive and HPV-negative of HNSCC tissues were screened out.Then,referring to the oncogene and tumor suppressor gene information in COSMIC and TSGene2.0 database,the genes that might make the prognosis of HNSCC patients with HPV positive better than that with HPV negative were selected.According to the survival analysis,MAP4K1,IKZF3,MZB1,TSPAN32,CCND1,CDK6and WT1were found to be correlated with the prognosis of HPVassociated HNSCC,which provides new potential targets for clinical diagnosis and treatment of HNSCC.