摘要
目的分析他汀类药物强化治疗青年急性脑梗死的临床疗效。方法70例青年急性脑梗死患者,以随机分组法分为对照组(39例)与实验组(31例)。对照组采取常规药物进行治疗,实验组采取他汀类药物强化治疗。比较两组治疗效果以及治疗前后血脂[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平、美国国立卫生研究院卒中量表(NIHSS)评分、Rankin评分。结果实验组治疗总有效率96.77%高于对照组的79.49%,差异具有统计学意义(P<0.05)。治疗后,实验组患者HDL-C(1.34±0.25)mmol/L高于对照组的(1.19±0.24)mmol/L,LDL-C(1.97±0.42)mmol/L、TC(4.03±1.01)mmol/L、TG(1.57±0.43)mmol/L均低于对照组的(2.19±0.41)、(4.61±1.03)、(1.78±0.41)mmol/L,差异均具有统计学意义(P<0.05)。治疗后,实验组患者NIHSS评分(6.58±2.37)分、Rankin评分(1.04±0.25)分均低于对照组的(7.91±2.41)、(1.28±0.29)分,差异均具有统计学意义(P<0.05)。结论给予青年急性脑梗死患者他汀类药物强化治疗具有理想效果,可降低血脂水平,改善神经功能及预后情况,具有应用价值。
Objective To analyze the clinical effect of intensive treatment of acute cerebral infarction with statins in young patients.Methods A total of 70 young patients with acute cerebral infarction were randomly divided into control group(39 cases)and experimental group(31 cases).The control group was treated with conventional drugs,and the experimental group was treated with statins for intensive treatment.Both groups were compared in terms of therapeutic effect,blood lipids[triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]levels before and after treatment,National Institutes of Health stroke scale(NIHSS)score,Rankin score.Results The total effective rate of treatment 96.77%in the experimental group was higher than 79.49%in the control group,and the difference was statistically significant(P<0.05).After treatment,HDL-C(1.34±0.25)mmol/L in the experimental group was higher than(1.19±0.24)mmol/L in the control group,and LDL-C(1.97±0.42)mmol/L,TC(4.03±1.01)mmol/L and TG(1.57±0.43)mmol/L were lower than(2.19±0.41),(4.61±1.03)and(1.78±0.41)mmol/L of the control group.All the differences were statistically significant(P<0.05).After treatment,NIHSS score(6.58±2.37)points and Rankin(1.04±0.25)points of the experimental group were lower than(7.91±2.41)and(1.28±0.29)points of the control group,and the differences were statistically significant(P<0.05).Conclusion Intensive treatment with statins has ideal effect in young patients with acute cerebral infarction,and it can promote the decrease of blood lipid level,improve neurological function and prognosis,and has application value.
作者
郑圆
ZHENG Yuan(Suqian First People’s Hospital,Suqian 223800,China)
出处
《中国现代药物应用》
2021年第19期96-98,共3页
Chinese Journal of Modern Drug Application
关键词
他汀类药物强化
青年
急性脑梗死
临床疗效
Intensive treatment with statins
Youth
Acute cerebral infarction
Clinical efficacy