莫西沙星治疗结核合并肺炎的效果研究

Study on the effect of moxifloxacin in the treatment of tuberculosis complicated with pneumonia

目的分析结核合并肺炎患者使用莫西沙星治疗的效果。方法78例结核合并肺炎患者,以抽签法分为A组与B组,各39例。A组予以莫西沙星治疗,B组予以常规治疗。对比两组治疗总有效率、不良反应发生率、炎性指标水平。结果A组治疗总有效率为94.87%,高于B组的76.92%,差异有统计学意义(P<0.05)。A组的不良反应发生率为5.13%,低于B组的20.51%,差异有统计学意义(P<0.05)。治疗后,两组的C反应蛋白(CRP)、中性粒细胞计数(NE)、白细胞计数(WBC)和红细胞沉降率(ESR)均低于治疗前,且A组CRP、NE、WBC、ESR分别为(58.69±5.47)mg/L、(7.61±1.20)×10^(9)/L、(9.82±1.66)×10^(9)/L、(50.36±5.12)mm/h,均低于B组的(66.95±5.58)mg/L、(9.65±1.24)×10^(9)/L、(12.68±1.95)×10^(9)/L、(55.78±5.29)mm/h,差异有统计学意义(P<0.05)。结论为结核合并肺炎患者实行莫西沙星治疗可改善其疗效和炎性指标,且用药安全性高,具有较高的推广性。

Objective To analyze the effect of moxifloxacin in the treatment of tuberculosis complicated with pneumonia.Methods A total of 78 patients with tuberculosis and pneumonia were divided into group A and group B according to the method of drawing lots,with 39 cases in each group.Group A was treated with moxifloxacin,and group B was treated with conventional therapy.Both groups were compared in terms of therapeutic effect,incidence of adverse reactions and inflammatory index.Results The total effective rate of treatment in group A was 94.87%,which was higher than 76.92%in group B,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in group A was 5.13%,which was lower than 20.51%in group B,and the difference was statistically significant(P<0.05).After treatment,the C-reactive protein(CRP),neutrophil count(NE),white blood cell count(WBC)and erythrocyte sedimentation rate(ESR)in both groups were lower than those before treatment;CRP,NE,WBC and ESR in group A were(58.69±5.47)mg/L,(7.61±1.20)×10^(9)/L,(9.82±1.66)×10^(9)/L,(50.36±5.12)mm/h,which were lower than(66.95±5.58)mg/L,(9.65±1.24)×10^(9)/L,(12.68±1.95)×10^(9)/L,(55.78±5.29)mm/h in group B;all the differences were statistically significant(P<0.05).Conclusion Moxifloxacin treatment for tuberculosis patients with pneumonia can improve its efficacy and inflammatory indicators with high medication safety,and has high promotion.