维生素E应用于UHMWPE人工关节的进展

A Review on Applying Vitamin E in UHMWPE Artificial Joint

超高分子量聚乙烯(UHMWPE)人工关节置换材料发展至今仍面临许多难题。例如,加工过程中的高温和辐照使材料中自由基增多,加速植入物氧化,导致材料力学性能、耐疲劳性过早失效,最终导致植入物脆变、表面剥离,增加了患者二次手术的隐患。目前,采用维生素E稳定交联UHWMPE是最新的植入物成型方法,该方法通过在UHMWPE型材制备过程中添加维生素E来清除周围自由基,减少植入物体内氧化,降低UHWMPE的磨损率,从而提高人工关节使用寿命,避免患者骨溶解。维生素E的抗氧化机理主要是与自由基发生反应,其添加方式有共混模压法和模压浸泡法2种,维生素E的添加量与辐照剂量共同影响材料的制备与性能,维生素E在用于稳定UHMWPE人工关节置换材料方面效果显著,是目前应用较成熟的一种抗氧化手段。

With the development of ultra-high molecular weight polyethylene(UHMWPE)artificial joint replacement materials,the main problem is that the high temperature and irradiation in the processing process cause the increase of free radicals in the materials,accelerate the oxidation of implants,and premature failure of mechanical properties and fatigue resistance,which eventually leads to the implant embrittlement and surface peeling,which increases the hidden danger of secondary surgery for patients.Using vitamin E to stabilize cross-linked UHWMPE has become the latest implant molding method.By adding vitamin E in the UHMWPE molding process,eliminating the surrounding free radicals,reducing the oxidation and wear rate of UHWMPE,so as to improving the service life of artificial joints and avoiding osteolysis of patients.The antioxidant mechanism of vitamin E is mainly reaction with free radicals.At present,there are two methods by which vitamin E can be incorporated into UHMWPE:blending-molding and doping.The amount of vitamin E and irradiation dose affect the preparation and properties of materials together.Vitamin E has a significant effect in stabilizing UHMWPE artificial joint replacement material,and it is a well-considered antioxidant method.