轮状病毒疫苗对轻度胃肠炎伴婴幼儿良性惊厥的影响

Effect of rotavirus vaccine on benign infantile convulsion with mild gastroenteritis in Hami city

目的探讨轻度胃肠炎伴发良性婴儿惊厥(BICE)的发病概况,分析轮状病毒疫苗接种对其发病的影响。方法收集2016-01—2020-12哈密市六家医院的140例住院BICE患儿的临床表现特点、实验室检查结果,进行回顾性分析。结果 140例患儿中男63例,女77例,男∶女=1∶1.2,发病年龄(20.75±10.23)个月,民族以汉族(75.71%)、维吾尔族(15.00%)、哈萨克族(5.71%)为主,发病季节以春、秋季节为主。与未接种组比较,接种组在惊厥发作类型和发作次数差异无统计学意义(P>0.05),但接种组胃肠炎与惊厥的间隔时间更短,差异有统计学意义(P<0.05)。接种组低钠血症、低钙血症、心肌酶异常发生率高于未接种组,差异有统计学意义(P<0.05)。结论中国西北地区BICE发生率为1.5%(140/9 334),接种轮状病毒疫苗对于BICE的惊厥发作有一定影响。

Objective To explore the incidence of mild gastroenteritis with benign infant convulsion(BICE),and analyze the impact of rotavirus vaccination on its incidence.MethodsClinical features and laboratory examination results of 140 hospitalized children with BICE in 6 hospitals of Hami City from January 2016 to December 2020 were collected for retrospective analysis.ResultsAmong the 40 cases,there were 63 males and 77 females,male ∶ female=1 ∶ 1.2. The mean age of onset was(20.75±10.23)months. The majority of ethnic groups were Han(75.71%),Uygur(15.00%)and Kazak(5.71%). The onset season was mainly in spring and autumn. Compared with the uninoculated group,there was no difference in the type and frequency of seizures in the inoculated group(P>0.05),but the interval between gastroenteritis and convulsion in the inoculated group was shorter,and the difference was statistically significant(P<0.05). The incidence of hyponatremia,hypocalcemia and abnormal myocardial enzymes in the inoculated group were higher than those in the non-inoculated group,with statistical significance(P<0.05).ConclusionThe incidence of BICE in Northwest China was 1.5%(140/9334),and the inoculation of rotavirus vaccine had a certain influence on the seizure of BICE.