多取代吡咯的合成及其性质(Ⅱ)

Synthesis and Propertion of Polysubstitution Pyrrole

前文已报导1-芳基-2-甲基-3-乙酰基-5-对氯苯基吡咯^([1])。本文用间硝基-ω-溴代苯乙酮^([2])与乙酰丙酮作用,得到1-间硝基苯基-3-乙酰基-1,4-戊二酮(1)^([3]),(1)与各种不同的芳香族伯胺在冰醋酸存在下进行环合反应,生成1,2,3,5-四取代吡咯(2)至(10)^([4])。后者与氨基脲反应得到相应的缩氨脲^([5,6])。这些都是新化合物,其性质见下。

Acetylacetones were treated by m-nitro-ω-bromoacetophenones to give l-(m-nitrophenyl) -3-acetyl-1, 4-pentandiketone( 1 ). 9 new 1-aryl-2-methyl-3-acetyl-5-(m-nitrophenyl)pyrroles (2)-( 10) have been synthesized by reaction of (1)with various primary amines. Semicarbazoncs were prepared from (2)-(10).Compounds(1)-(10) and the Semicarbazoncs were reported for the first time.