正性肌力药物在心力衰竭患者中的应用进展

Application Progress of Positive Inotropic Drugs in Patients with Heart Failure

心力衰竭是各种心脏疾病的严重表现或终末期阶段,临床常采用传统正性肌力药物(强心苷类药物、儿茶酚胺类药物等)及新型肌力药物(钙离子增敏剂、磷酸二酯酶抑制剂等)进行治疗,虽有一定疗效,但药物引起的不良反应及不良结局不可忽视。本文结合现有研究对正性肌力药物在心力衰竭患者中的应用进展进行综述,以期为临床合理用药提供参考。

Heart failure is a serious manifestation or end stage of various heart diseases.In clinic,traditional positive inotropic drugs(cardiac glycosides,catecholamines,etc.)and new positive inotropic drugs(calcium sensitizers,phosphodiesterase inhibitors,etc.)are often used for the treatment of heart failure.Although there is a certain curative effect,the adverse reactions and adverse outcomes caused by drugs can not be ignored.In this paper,the application progress of positive inotropic drugs in patients with heart failure is reviewed,in order to provide reference for clinical rational drug use.