间歇性内分泌治疗联合中药治疗晚期前列腺癌的近期疗效观察

Short-term efficacy of intermittent endocrine therapy combined with traditional Chinese medicine in the treatment of advanced prostate cancer

目的:探讨间歇性内分泌治疗联合中药治疗晚期前列腺癌(PCa)的近期疗效观察。方法:选取2018年01月至2020年05月海南西部中心医院收治的96例晚期PCa患者,按随机数表法将其分为对照组(n=48)和观察组(n=48)。对照组采用间歇性内分泌治疗,观察组采用间歇性内分泌联合中药治疗。比较两组患者治疗前和治疗6个月后生活质量、血清PSA及VEGF水平。观察两组患者的临床疗效及不良反应发生情况。结果:观察组和对照组治疗后性功能、泌尿功能、肠道功能及激素功能评分均明显低于治疗前(P<0.05)。观察组治疗后性功能[(85.50±4.38)分vs(78.80±4.72)分]、泌尿功能[(41.74±4.05)分vs(32.37±3.70)分]、肠道功能[(87.35±8.46)分vs(80.62±7.72)]及激素功能[(78.35±7.62)分vs(70.48±7.28)分]评分均明显高于对照组(P<0.05)。观察组和对照组治疗后血清PSA及VEGF水平均明显低于治疗前(P<0.05),而观察组和对照组治疗后血清PSA[(4.42±1.26)ng/mL vs(4.80±1.37)ng/mL]及VEGF[(69.83±7.50)ng/mL vs(73.25±8.18)ng/mL]水平比较,差异均无统计学意义(P>0.05)。观察组治疗后的总有效率(87.5%vs 66.7%)明显优于对照组(P<0.05)。观察组和对照组治疗期间不良反应发生率(29.2%vs 22.9%)比较,差异无统计学意义(P>0.05)。结论:间歇性内分泌治疗联合中药治疗PCa具有较好的疗效,能够改善患者生活质量和降低PSA水平,且不增加不良反应。

Objective:To investigate the quality of life and short-term efficacy of intermittent endocrine therapy combined with traditional Chinese medicine in the treatment of advanced prostate cancer(PCa).Methods:Ninety-six patients with advanced PCa admitted to Hainan West Central Hospital from January 2018 to May 2020 were randomly divided into control group(n=48)and observation group(n=48).The control group was treated with intermittent endocrine therapy,while the observation group was treated with intermittent endocrine combined with traditional Chinese medicine.The quality of life,serum PSA and VEGF levels were compared between the two groups before and after treatment for six months.The clinical efficacy and adverse reactions of the two groups were observed.Results:The scores of sexual function,urinary function,intestinal function and hormone function in the observation group and the control group after treatment were significantly lower than those before treatment(P<0.05).The scores of sexual function[(85.50±4.38)ponts vs(78.80±4.72)points],urinary function[(41.74±4.05)ponts vs(32.37±3.70)points],intestinal function[(87.35±8.46)points vs(80.62±7.72)points]and hormone function[(78.35±7.62)ponts vs 70.48±7.28)points]in the observation group were significantly higher than those in the control group(P<0.05).The levels of serum PSA and VEGF in the observation group and the control group after treatment were significantly lower than those before treatment(P<0.05),while there was no significant difference in serum PSA[(4.42±1.26)ng/mL vs(4.80±1.37)ng/mL]and VEGF[(69.83±7.50)ng/mL vs 73.25±8.18)ng/mL]between the observation group and the control group after treatment(P>0.05).The total effective rate of the observation group(87.5%vs 66.7%)was significantly better than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions(29.2%vs 22.9%)between the observation group and the control group(P>0.05).Conclusion:Intermittent endocrine therapy combined with traditional Chinese medicine has good curative effect on PCa,can improve the quality of life and reduce the level of PSA,and does not increase the adverse reactions.