软组织肉瘤的免疫治疗进展

Progress in immunotherapy of soft tissue sarcoma

软组织肉瘤(soft tissue sarcoma,STS)是一组分型复杂、具有高度异质性的间叶源性恶性肿瘤,手术是其主要的治疗手段。虽然化疗是复发转移STS患者的姑息一线治疗选择,但疗效有限。近年来免疫治疗在STS中进行了广泛探索,本文将就STS的免疫学特征,以及免疫检查点抑制剂、过继性细胞疗法、肿瘤疫苗等新型免疫治疗药物及技术在STS中的应用进行梳理。

Soft tissue sarcoma(STS)is a complex and heterogeneous group of mesenchymal malignancies,and surgery is its core curative treatment.Although chemotherapy has been the therapeutic standard of care for most recurrent and metastatic STS,the efficacy remains limited.Immunotherapy for STS has been explored as a promising approach in recent years.In this article,we review the immune characteristics of STS and the investigations of immunotherapy including immune checkpoint inhibitors,adoptive cell therapy and cancer vaccines in STS.