盐酸美金刚联合维生素E治疗对痴呆患者临床疗效的影响

Effect of memantine hydrochloride combined with vitamin E on the clinical efficacy of dementia patients

目的探究盐酸美金刚联合维生素E治疗对痴呆患者临床疗效及简易智力状态检查量表(MMSE)和日常生活活动能力(ADL)的影响。方法选取2018年1月至2020年4月本院收治的痴呆患者126例,随机分成两组,每组63例。对照组采用盐酸美金刚治疗,研究组进行盐酸美金刚联合维生素E治疗。比较两组患者的临床治疗效果、MMSE、ADL评分和不良反应发生情况。结果与对照组比较,研究组治疗总有效率更高(P<0.05)。治疗前,两组MMSE评分比较差异无统计学意义;治疗后8周、16周,与对照组比较,研究组MMSE评分更高(P<0.05),与治疗后8周比较,研究组治疗后16周的MMSE评分较高(P<0.05)。与对照组比较,研究组日常生活自理能力评分较高(P<0.05)。与对照组比较,研究组不良反应发生率较低(P<0.05)。结论应用盐酸美金刚联合维生素E治疗痴呆症状可以明显增强患者的认知能力、日常生活自理能力,改善患者的生存质量,能够降低药物不良反应发生率,提高治疗安全性,促使痴呆症状的临床治疗效果趋于理想化,值得推广应用。

Objective To explore the effect of memantine hydrochloride combined with vitamin E on clinical efficacy,MMSE and ADL scores of patients with dementia.Methods 126 dementia patients admitted to our hospital from January 2018 to April 2020 were randomly divided into two groups,with 63 cases in each group.The control group received memangine hydrochloride treatment,while the study group received memangine hydrochloride combined with vitamin E treatment.The clinical treatment effect,MMSE,ADL and adverse reactions were compared between the two groups.Results Compared with the control group,the total effective rate of the study group was higher(P<0.05).Before treatment,MMSE scores of the two groups were not significantly different.At 8 and 16 weeks after treatment,MMSE scores of the study group were higher than those of the control group(P<0.05),compared with 8 weeks after treatment,the MMSE score of the study group at 16 weeks after treatment was higher(P<0.05).Compared with the control group,the score of self-care ability in daily life in the study group was higher(P<0.05).Compared with the control group,the incidence of adverse reactions in the study group was lower(P<0.05).Conclusion The application of combined vitamin E hydrochloride dollars just treat dementia symptoms can significantly enhance the patient's cognitive ability,the ability to care for daily life,to further improve the patient's quality of life,at the same time can continue to reduce the patients incidence of adverse reactions,improve the safety,prompt clinical therapeutic effect of the symptoms of dementia tend to idealize,is worthy of popularization and application.