电压门控钠离子通道与相关癫痫研究

Research on voltage-gated sodium channels and related epilepsy

癫痫是神经系统常见病,离子通道是各种无机离子跨膜被动转运的通路,离子通道在癫痫的阵发性异常放电过程中发挥了重要作用。离子通道突变是常见癫痫的罕见致病原因,也是罕见的单基因特发性癫痫的常见致病原因。本文对钠离子通道基因与相关性癫痫的研究进行综述。

Epilepsy is a common disease of the nervous system,and ion channels are the pathway of passive transport of various inorganic ions across the membrane.Ion channels play an important role in the paroxysmal abnormal discharge of epilepsy.Ion channel mutation is not only a rare cause of common epilepsy,but also a common cause of rare monogenic idiopathic epilepsy.This article reviews the research on sodium channel gene and related epilepsy.