扶正抗癌汤辅助治疗乳腺癌术后放化疗患者的效果

Effect of Fuzheng Anticancer Decoction on Adjuvant Treatment of Breast Cancer Patients with Postoperative Radiotherapy and Chemotherapy

目的探讨扶正抗癌汤辅助治疗乳腺癌术后放化疗患者的临床效果。方法选取2012年1月至2015年4月河南省中医院收治的90例乳腺癌患者为研究对象。通过随机数表法将所选对象分为对照组和观察组,各45例。对照组患者入院后接受乳腺癌改良根治术治疗,术后接受表阿霉素、环磷酰胺联合多西他赛化疗,以及放疗。观察组在对照组的基础上于术后加用扶正抗癌汤辅助治疗。比较两组治疗前后T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、欧洲癌症生活质量核心量表(EORTC-QLQ-C30)评分。记录患者5 a预后情况,包括总生存时间(OS)、无进展生存时间(PFS)。结果治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05);治疗后,两组CD8^(+)水平低于治疗前,观察组CD8^(+)水平高于对照组(P<0.05)。治疗后,两组EORTC-QLQ-C30各维度评分均较治疗前上升,观察组EORTC-QLQ-C30各维度评分高于对照组(P<0.05)。观察组5 a OS率和PFS率较对照组高(P<0.05)。结论乳腺癌术后放化疗期间联合扶正抗癌汤辅助治疗不仅可有效提高生活质量,还可以改善患者的免疫力,延长生存时间。

Objective To explore the clinical effect of Fuzheng anticancer decoction in the adjuvant treatment of breast cancer patients with postoperative radiotherapy and chemotherapy.Methods Ninety patients with breast cancer admitted to Henan Provincial Hospital of Traditional Chinese Medicine from January 2012 to April 2015 were selected as the research objects.The selected subjects were divided into control group and observation group by the random number table method,each with 45 cases.The patients in control group received modified radical mastectomy for breast cancer after admission,and received epirubicin,cyclophosphamide combined with docetaxel chemotherapy,and radiotherapy after surgery.On the basis of the control group,the observation group was treated with Fuzheng anticancer decoction after the operation.T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and the scores of European cancer quality of life core scale 30(EORTC-QLQ-C30)were compared between the two groups before and after treatment.The patients’5-year prognosis were recorded,including overall survival time(OS)and progression-free survival time(PFS).Results After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before treatment,and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in observation group were higher than those in control group(P<0.05).The levels of CD8^(+)in the two groups after treatment were lower than those before treatment,and the level of CD8^(+)in observation group was higher than that in control group(P<0.05).After treatment,the scores of all dimensions of EORTC-QLQ-C30 in the two groups were higher than those before treatment,and the scores of all dimensions of EORTC-QLQ-C30 in observation group were higher than those in control group(P<0.05).The 5-year OS rate and PFS rate in observation group were higher than those in control group(P<0.05).Conclusion Combined with Fuzheng anticancer decoction adjuvant therapy during postoperative radiotherapy and chemotherapy for breast cancer can not only effectively improve the quality of life,but also improve the patient’s immunity and prolong survival time.