摘要
利用CGGA数据库,采集325例胶质瘤患者基因表达和临床信息,探讨蛋白酶体亚单位β-8(PSMB8)mRNA表达水平与胶质瘤患者临床特征及预后的关系。结果显示PSMB8 mRNA在高级别胶质瘤患者和异柠檬酸脱氢酶1野生型(IDH1-wt)患者中高表达。Pearson相关分析显示PSMB8与其他PSMB基因相关,表明PSMB8 mRNA表达与胶质瘤的恶性表型呈正相关,与总生存期(OS)呈负相关。推测抑制PSMB8可作为治疗PSMB8高表达胶质瘤的一种新方案。
To investigate the relationship between proteasome 20S subunit beta 8(PSMB8)mRNA expression and clinical characteristics and prognosis of glioma patients.325 patients with gliomas were from CGGA.PSMB8 mRNA was enriched in high-grade glioma and isocitrate dehydrogenase 1 wild-type(IDH1-wt)group.Pearson correlation test showed that PSMB8 was correlated with other PSMB8 genes.PSMB8 mRNA expression was positively correlated with malignant phenotype and negatively correlated with overall survival(OS),suppression of PSMB8 may be taken as a new strategy for the treatment of PSMB8 over expressing gliomas.
作者
龙腾飞
张红雁
吴爱林
高劲
刘鹤飞
柳璐
张琦
Long Tengfei;Zhang Hongyan;Wu AiLin(Dept of Tumor Radiotherapy,Hefei Ion Medical Center,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230088;Dept of Tumor Radiotherapy,The First Affiliated Hospital of University of Science and Technology of China West District(Anhui Provincial Cancer Hospital),Hefei 230031)
出处
《安徽医科大学学报》
CAS
北大核心
2021年第11期1833-1837,共5页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金(编号:11805198)。
