血常规中红细胞参数检验在地中海贫血诊断中的价值

The value of erythrocyte parameter tests in blood routine in the diagnosis of thalassemia

目的研究血常规红细胞参数检验在地中海贫血诊断中的价值。方法选择地中海贫血患者作为研究1组,缺铁性贫血确诊患者作为研究2组以及同期接受体检健康者作为对照组,各50例。对三组血红蛋白、平均红细胞血红蛋白浓度、平均红细胞血红蛋白量、红细胞分布宽度、红细胞平均体积、红细胞计数水平等6项血常规红细胞参数进行检测,并且对比6项指标检测结果的阳性率。结果研究2组血红蛋白(83.76±3.49)g/L、平均红细胞血红蛋白浓度(258.61±8.75)g/L均低于研究1组的(102.95±4.26)、(278.16±10.30)g/L,研究1组均低于对照组的(113.60±4.72)、(332.85±12.94)g/L;研究1组平均红细胞血红蛋白量(21.29±0.85)pg、红细胞分布宽度(61.27±3.59)fl、红细胞计数(3.06±0.15)×10^(9)/L均低于研究2组的(23.27±1.62)pg、(76.94±4.51)fl、(4.29±0.37)×10^(9)/L,研究2组均低于对照组的(26.83±2.14)pg、(88.62±4.75)fl、(5.36±0.39)×10^(9)/L;研究2组红细胞平均体积(21.85±4.16)%高于研究1组的(18.95±2.17)%,研究1组高于对照组的(10.62±3.57)%;差异均具有统计学意义(P<0.05)。研究2组血红蛋白、平均红细胞血红蛋白浓度、红细胞平均体积检测阳性率高于研究1组,且研究1组高于对照组;研究1组红细胞计数、红细胞分布宽度、平均红细胞血红蛋白量检测阳性率高于研究2组,且研究2组高于对照组;差异均具有统计学意义(P<0.05)。结论地中海贫血患者的血常规红细胞参数水平与正常健康人群和缺铁性贫血患者比较存在明显异常,临床上可将该特征作为对地中海贫血进行鉴别的重要参考依据。

Objective To study the value of erythrocyte parameter tests in blood routine in the diagnosis of thalassemia.Methods 50 patients with thalassemia were taken as research group 1,50 patients with iron deficiency anemia were taken as research group 2,and 50 healthy subjects who received physical examination during the same period were taken as control group.Six blood routine erythrocyte parameters,including hemoglobin,mean corpuscular hemoglobin concentration,mean corpuscular hemoglobin,red blood cell distribution width,mean corpuscular volume,and red blood cell count level,were tested in the three groups,and the levels of positive rates of the six indexes were compared.Results The hemoglobin(83.76±3.49)g/L and mean corpuscular hemoglobin concentration(258.61±8.75)g/L of the research group 2 were lower than(102.95±4.26)and(278.16±10.30)g/L of the research group 1,and those indicators in the research group 1 were lower than(113.60±4.72)and(332.85±12.94)g/L in the control group;the mean corpuscular hemoglobin(21.29±0.85)pg,red blood cell distribution width(61.27±3.59)fl,and red blood cell count(3.06±0.15)×10^(9)/L of research group 1 were lower than(23.27±1.62)pg,(76.94±4.51)fl and(4.29±0.37)×10^(9)/L of research group 2,and those indicators in the research group 2 were lower than(26.83±2.14)pg,(88.62±4.75)fl and(5.36±0.39)×10^(9)/L in the control group;the mean corpuscular volume(21.85±4.16)%of research group 2 was higher than(18.95±2.17)%of research group 1,and the mean corpuscular volume of the research group 1 was higher than(10.62±3.57)%of the control group.All the differences were statistically significant(P<0.05).The positive rate of hemoglobin,mean corpuscular hemoglobin concentration,mean corpuscular volume of the research group 2 was higher than those of the research group 1,and the research group 1 was higher than the control group.The positive rate of red blood cell count,red blood cell distribution width,and mean corpuscular hemoglobin concentration in the research group 1 was higher than those in the research group 2,and the research group 2 was higher than the control group.All the differences were statistically significant(P<0.05).Conclusion Compared with normal people and iron-deficiency anemia patients,there are obvious abnormalities in blood routine erythrocyte parameters of thalassemia patients.This feature can be used as an important reference for the identification of thalassemia.