血清内NLR、PLR及RDW与慢性乙肝患者病情发展的相关性分析

Correlation analysis of serum NLR,PLR and RDW with disease development of chronic hepatitis B patients

目的考察血清内中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及红细胞分布宽度(RDW)与慢性乙肝患者病情发展的相关性分析。方法选取2020年1—11月于我院诊治的慢性乙肝患者90例,根据病情进展分为慢性重型乙肝患者40例(重型组)及慢性乙肝患者50例(普通组),另选取同期健康体检者50例(对照组),比较三组患者的一般临床资料,并采用Logistic回归分析及Spearman相关性分析各因素与慢性乙肝患者病情进展的相关性。结果相比于对照组,重型组和普通组患者的NLR、RDW、AST及ALT均显著提高,PLR显著降低,差异有统计学意义(P<0.05);相比于普通组,重型组患者的NLR、RDW、AST及ALT均显著提高,PLR显著降低,差异有统计学意义(P<0.05);Logistic多因素回归分析结果显示,血清内NLR、PLR及RDW是慢性乙肝患者病情进展的危险因素(P<0.05);Spearman相关性结果显示,NLR、RDW与慢性乙肝患者病情进展呈显著正相关(r=0.633、0.376),PLR与病情进展呈显著负相关(r=-0.252)。结论血清内NLR、PLR及RDW与慢性乙型肝炎患者的病情进展具有相关性,临床应密切监测。

Objective To investigate and analyze the correlation between the neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR)and red blood cell distribution width(RDW)in serum and disease progression in patients with chronic hepatitis B.Methods A total of 90 chronic hepatitis B patients who were treated in our hospital from January to November 2020 were selected and divided into 40 severe chronic hepatitis B patients(the severe group)and 50 chronic hepatitis B patients(the normal group)according to their disease progression.Another 50 healthy subjects(the control group)were selected during the same period.The general clinical data of the three groups were compared.Logistic regression analysis and Spearman correlation analysis were used to analyze the correlation between each factor and the disease progression of patients with chronic hepatitis B.Results Compared with the control group,NLR,RDW,AST and ALT in the severe group and the normal group were significantly increased,while PLR was significantly decreased,with statistically significant differences(P<0.05).Compared with the normal group,NLR,RDW,AST and ALT in the severe group were significantly increased,while PLR was significantly decreased,with statistically significant differences(P<0.05).According to Logistic multivariate regression analysis,serum NLR,PLR and RDW were the risk factors of the disease progression of chronic hepatitis B patients(P<0.05).According to Spearman correlation results,NLR and RDW were significantly positively correlated with the disease progression of patients with chronic hepatitis B(r=0.633,0.376),and PLR was significantly negatively correlated with the disease progression(r=-0.252).Conclusion Serum NLR,PLR and RDW are correlated with the disease progression of patients with chronic hepatitis B,which should be closely monitored in clinic.