孟鲁司特钠联合复方异丙托溴铵治疗老年支气管哮喘急性发作患者的临床疗效

Clinical effect of montelukast sodium combined with compound ipratropium bromide on elderly patients with acute attack of bronchial asthma

目的 探讨孟鲁司特钠联合复方异丙托溴铵治疗老年支气管哮喘急性发作患者的疗效。方法 选取2018年12月至2019年12月医院收治的102例老年支气管哮喘急性发作患者为研究对象,随机分为对照组和研究组,每组各51例,对照组在常规治疗基础上采用复方异丙托溴铵吸入治疗,研究组在常规治疗的基础上采用孟鲁司特钠片联合复方异丙托溴铵吸入治疗。比较两组临床疗效、肺功能指标(PEF、FEV1%、FVC)及临床症状积分。结果 研究组患者总有效率高于对照组,差异有统计学意义(P<0.05)。研究组和对照组治疗后的临床症状(喘息、咳嗽、气促)积分低于治疗前,差异有统计学意义(P<0.05);研究组治疗后的临床症状积分低于同期对照组,差异有统计学意义(P<0.05)。研究组和对照组治疗后的肺功能指标(PEF、FEV1%、FVC)高于治疗前,差异有统计学意义(P<0.05);研究组治疗后的肺功能指标高于同期对照组,差异有统计学意义(P<0.05)。结论 老年支气管哮喘急性发作患者应用复方异丙托溴铵或者孟鲁司特钠联合复方异丙托溴铵治疗均可收到显著的效果,但是孟鲁司特钠联合复方异丙托溴铵治疗效果更好,能有效缓解患者的临床症状,改善患者的肺功能,优于单独应用复方异丙托溴铵治疗。

Objective To investigate the efficacy of montelukast sodium combined with compound ipratropium bromide in the treatment of elderly patients with acute attack of bronchial asthma.Methods A total of 102 elderly patients with acute attack of bronchial asthma who were admitted to our hospital from December 2018 to December 2019 were selected as the research subjects and randomly divided into the control group and the research group,with 51 cases in each group.The control group was treated with inhalation of compound ipratropium bromide on the basis of conventional treatment,while the research group was treated with montelukast sodium tablets combined with inhalation of compound ipratropium bromide on the basis of conventional treatment,Clinical efficacy,pulmonary function indexes(PEF,FEV1%,FVC)and clinical symptom scores were compared between the two groups.Results The total effective rate in the research group was higher than that in the control group,and the difference was statistically significant(P<0.05).The score of clinical symptoms(wheezing,cough,anhelation)in the research group and the control group after treatment was lower than that before treatment,and the difference was statistically significant(P<0.05).The clinical symptom score of the research group was lower than that of the control group,and the difference was statistically significant(P<0.05).The pulmonary function indexes(PEF,FEV1%,FVC)in the research group and the control group after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The pulmonary function indexes in the research group after treatment were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment with compound ipratropium bromide or montelukast sodium combined with compound ipratropium bromide in elderly patients with acute attack of bronchial asthma can obtain significant effects.However,montelukast sodium combined with compound ipratropium bromide has a better therapeutic effect,which can effectively alleviate the clinical symptoms and improve the pulmonary function of patients,and is superior to compound ipratropium bromide alone.