残余胆固醇与动脉粥样硬化性心血管疾病

Remnant Cholesterol and Atherosclerotic Cardiovascular Disease

动脉粥样硬化性心血管疾病(ASCVD)是全球公共健康的最大威胁之一,呈高发病率、年轻化的趋势,血脂代谢异常是其主要危险因素。残余胆固醇(RC)是空腹状态下极低密度脂蛋白残粒和中间密度脂蛋白残粒的胆固醇,餐后状态还包括乳糜微粒残粒的胆固醇。越来越多的证据表明,RC的水平与ASCVD的发生有关,特别是当低密度脂蛋白胆固醇在合适水平时,被认为是动脉粥样硬化脂蛋白谱的又一特征。现总结RC的定义、定量评价,并通过流行病学、遗传学证据及治疗等方面探讨RC与ASCVD之间的关系。

Atherosclerotic cardiovascular disease(ASCVD)is one of the biggest threats to public health worldwide.It is a trend of high incidence rate and younger age.Abnormal lipid metabolism is the main risk factor.Remnant cholesterol(RC)is the cholesterol of very low density lipoprotein and intermediate density lipoprotein in fasting state,and the cholesterol of chylomicrons in postprandial state.More and more evidence shows that the level of RC is related to the occurrence of ASCVD,especially when low density lipoprotein cholesterol is at the appropriate level,it is considered to be another feature of atherosclerotic lipoprotein profile.This review summarizes the definition and quantitative evaluation of RC,and demonstrates the relationship between RC and ASCVD through and epidemiology evidence,genetic evidence and treatment.