复合纳米粒子修饰的柔性分子印迹传感器对四环素的检测研究

Detection of Tetracycline by Flexible Molecularly Imprinted Sensor Modified with Composite Nanoparticle

本文以酸化碳布(CC)作为柔性工作电极,采用恒电位沉积法在碳布上修饰纳米Au-Cu复合粒子(Au-Cu NPs),以四环素(TC)为模板分子,邻苯二胺为功能单体,采用循环伏安法在修饰了纳米粒子的活化碳布上电聚合分子印迹膜,制备了四环素分子印迹柔性传感器(Cu-Au NPs/PANI/TC/CC),通过循环伏安法(CV)、差分脉冲伏安法(DPV)研究了其电化学性能。结果显示,在优化实验条件下,TC的DPV峰值电流与其浓度在1.0×10^(-7)~3.0×10^(-5)mol/L范围内成良好的线性关系,相关系数为0.9996,检出限为2.57×10^(-11)mol/L,实际样品的加标回收率为97.3%~105%。该传感器柔软稳定,灵敏度高,抗干扰性和重复性好,可应用于柔性可穿戴传感器的设计。

In this work,acidified carbon cloth was used as a flexible working electrode,and nano-gold-copper composite particles were modified on the carbon cloth by constant potential deposition.Using tetracycline(TC)as the template molecule and o-phenylenediamine as the functional monomer,a TC molecularly imprinted flexible sensor(CuAuNPs/PANI/TC/CC)was prepared by electropolymerization of molecularly imprinted membrane on activated carbon cloth modified with nanoparticles,which was studied by cyclic voltammetry(CV)and differential voltammetry(DPV).The results showed that under the optimal experimental conditions,the DPV peak current of TC had a good linear relationship with its concentration in the range of 1×10^(-7)-3×10^(-5)mol/L.The correlation coefficient was 0.9996,the detection limit was 2.5736×10^(-11)mol/L,and the spiked recovery of real samples was 97.3%-105%.The sensor is soft and stable with high sensitivity,good anti-interference ability and repeatability,and may be applied to the design of flexible wearable sensors.