自拟肝炎一号方对早期酒精性肝硬化患者肝功能指标的影响

Effect of self-made hepatitis No.1 Formula on liver function indexes in patients with early alcoholic cirrhosis

目的探讨自拟肝炎一号方对早期酒精性肝硬化患者肝功能指标的影响以及对临床症状改善情况。方法100例早期酒精性肝硬化患者接受口服复方甘草酸苷片(25 mg,2片/次,3次/天)治疗,其中50例在此基础上予口服自拟协定方(观察组),一日一剂,早晚分服,另50例为对照组。连续治疗3个月后,对比分析治疗前后2组患者的中医症状积分、腹水最深度、24 h尿量、体质量、肝功能指标(白蛋白、谷丙转氨酶、谷草转氨酶)。结果治疗前,2组症状积分、24 h尿量、肝功能指标、腹水最深度、体质量差异均无统计学意义(P>0.05);治疗后,2组上述指标均显著改善,且观察组优于对照组,差异均有统计学意义(P<0.05)。结论治疗早期酒精性肝硬化时联合自拟肝炎一号方,可显著改善患者的肝功能及临床症状,提高临床疗效。

Objective To explore the effect of self-made hepatitis No.1 Formula on liver function indexes in patients with early alcoholic cirrhosis and the improvement of clinical symptoms.Methods A total of 100 patients with early alcoholic liver cirrhosis were treated with compound glycyrrhizin tablets(25 mg,two tablets/time,three times/day).Among them,50 cases were treated with self-made hepatitis No.1 Formula(observation group),one dose a day in the morning and evening,and the other 50 cases were taken as the control group.After three months of continuous treatment,the TCM symptom score,the deepest ascites,24-hour urine volume,body mass and liver function indexes(albumin,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase)were compared and analyzed between the two groups before and after treatment.Results Before treatment,there was no significant difference in TCM symptom score,24-hour urine volume,liver function index,the deepest ascites and body mass between the two groups(P>0.05).After treatment,the above-mentioned indexes were significantly improved in both groups,and the observation group were better than the control group,and the differences were statistically significant(P<0.05).Conclusions In the treatment of early alcoholic liver cirrhosis,combined with self-made hepatitis No.1 Formula can significantly improve the liver function and clinical symptoms.