摘要
Cell reprogramming is the process of reverting mature,specialized cells into induced pluripotent stem cells.Reprogramming also refers to the erasure and re-establishment of epigenetic markers during the development of mammalian germ cells,such as DNA methylation[1].At present,reprogramming mainly refers to two processes:the process of reverting differentiated cells to a pluripotent state,and the process of transforming one type of differentiated cell into another[2].Reprogramming mainly includes induced pluripotent stem(iPS)cells,direct transdifferentiation,and indirect lineage conversion.
基金
by the Natural Science Foundation of Zhejiang Province(LR18C090001)
the National Natural Science Foundation of China(92049104,81801102,and 82071230)
the Research Start-up Project by Hangzhou Normal University(4125C5021920453 and 4125C50220204109).
