肠道:调控糖脂代谢稳态的前哨与枢纽

Intestinal tract:a sentry hub for maintaining glucose and lipid homeostasis

肠道是消化、吸收各种膳食营养素的重要场所,也是调节机体糖脂代谢稳态的主要器官。肠道可感受各种不同的营养信号,与脑、肝脏等代谢器官相互作用,形成复杂而又精细的糖脂代谢时空调控网络,发挥调节糖脂代谢稳态的"前哨"与"枢纽"作用。该领域的研究进展已成功转化为临床干预糖脂代谢紊乱的有效手段。本文将就该领域的基础理论和转化应用研究进展进行述评,并对该领域的未来研究热点提出展望。

The intestine is a primary organ for digestion and absorption of dietary nutrients.It also plays a pivotal role in regulating glucose and lipid metabolic homeostasis.Intestinal tract is able to sense various luminal nutrients,consequently triggers crosstalk with various metabolic tissues including brain and liver.This complex and delicate spatiotemporal network formed by inter-tissue crosstalk is considered crucial for maintaining glucose and lipid homeostasis,in which the intestine acts as a sentry hub.These significant outcomes have been clinically transformed as metabolic disease intervention.In this article,we prospected the promising research direction in future based on reviewing current outcomes of both basic research and transformation application in this hot field.