ADRA2A-1291C>G和CCK1R-779T>C基因遗传变异与肠易激综合征相关性的Meta分析

Association of ADRA2A-1291C>G and CCK1R-779T>C genetic polymorphism with irritable bowel syndrome:a Meta-analysis

目的探讨α2A肾上腺素能受体(ADRA2A)-1291C>G和胆囊收缩素受体1(CCK1R)-779T>C的多态性与肠易激综合征(irritable bowel syndrome,IBS)的关系。方法利用PubMed、Embase、ISI科学网和万方数据库的在线网站,在不限制语言的情况下,检索1996年6月至2019年5月的相关文献。结果ADRA2A-1291C>G的C等位基因和CCK1R-779T>C的T等位基因与IBS发病风险的增加密切相关。亚组分析表明,ADRA2A-1291C>G增加了显性模型中IBS-C(CC vs GG+CG:OR=1.38,95%CI:1.00~1.90)和IBS-D(CC vs GG+CG:OR=1.50,95%CI:1.06~2.14)的风险。结论ADRA2A-1291C>G的C等位基因与CCK1R-779T>C的T等位基因密切相关,提示IBS的危险性增加。为了验证其关联性,还需要更大的样本进行进一步的研究。

Objective To investigate the relationship between alpha 2A adrenergic receptor(ADRA2A)-1291C>G and cholecystokinin receptor 1(CCK1R)-779T>C polymorphism and irritable bowel syndrome(IBS).Methods The Meta-analysis was utilized to evaluate the associations between two polymorphisms and IBS.The online websites of PubMed,Embase,ISI Web of Science and WanFang database were collected to search the related literatures from Jun.1996 to May 2019 without limiting language.Results The C allele of ADRA2A-1291C>G and the T allele of CCK1R-779T>C were closely linked to an increased risk of IBS.Subgroup analysis suggested that ADRA2A-1291C>G increased the risk of IBS-C(CC vs GG+CG:OR=1.38,95%CI:1.00-1.90)and IBS-D(CC vs GG+CG:OR=1.50,95%CI:1.06-2.14)both in the dominant model.Conclusion There is a close relationship between the C allele of ADRA2A-1291C>G and the T allele of CCK1R-779T>C and an increased risk of IBS.Further researches controlled for the proper con-founders are still necessary to verify the pertinence.