缬沙坦与硝苯地平缓释片治疗原发性高血压的临床疗效

Clinical Efficacy of Valsartan and Nifedipine Sustained-release Tablets in the Treatment of Essential Hypertension

目的探讨治疗原发性高血压实施缬沙坦与硝苯地平缓释片治疗的临床效果。方法选入我院于2017年1月至2018年2月期间进行治疗的原发性高血压患者102例,以抽签法的形式将其分为研究组和对照组,分别为51例。对照组行缬沙坦治疗,研究组在此基础上用硝苯地平缓释片治疗,对比两组患者的降压效果,临床效果、不良反应。结果①研究组治疗前收缩压为(167.48±7.15)mm Hg,对照组为(168.65±7.17)mm Hg,组间对比无差异(t=0.8252,P=0.4112);治疗后,研究组收缩压为(131.19±5.12)mm Hg低于对照组的(143.07±9.22)mm Hg,组间具有差异(t=8.0446,P=0.0001);研究组治疗前舒张压为(104.85±7.14)mm Hg与对照组的(104.06±7.98)mm Hg相比,组间不具备统计学意义(t=0.5269,P=0.5994);研究组治疗后舒张压为(86.87±4.82)mm Hg比对照组的(95.77±4.53)mm Hg低,组间具有差异(t=9.6088,P=0.0001)。②研究组总有效率90.20%高于对照组的87.80%,组间对比(χ^(2)=13.4211,P=0.0002)。③研究组不良反应率为5.88%低于对照组的23.53%,组间对比具有差异(χ^(2)=14.4947,P=0.0001)。结论对于原发性高血压患者实施缬沙坦与硝苯地平缓释片治疗治疗,可以提高患者的治疗效果,改善血压情况,并且用药较为安全,不良反应少,值得在临床上推广和应用。

Objective To investigate the clinical effects of valsartan and nifedipine sustained-release tablets in the treatment of essential hypertension.Methods A total of 102 patients with essential hypertension who were treated in our hospital from January 2017 to February 2018 were enrolled in the study group and control group,51cases.The control group was treated with valsartan.On this basis,the research group used nifedipine sustained-release tablets to treat.The antihypertensive effect,clinical effect and adverse reactions of the two groups were compared.Results(1)The systolic blood pressure of the study group was(167.48±7.15)mm Hg,and that of the control group was(168.65±7.17)mm Hg.There was no difference between the groups(t=0.8252,P=0.4112).After treatment,the systolic blood pressure of the study group was(131.19±5.12)mm Hg was lower than that of the control group(143.07±9.22)mm Hg,there was a difference between the groups(t=8.0446,P=0.0001);the pre-treatment diastolic blood pressure of the study group was(104.85±7.14)mm Hg and the control group(104.06±7.98)mm Hg was not statistically significant between the groups(t=0.5269,P=0.5994);the diastolic blood pressure of the study group was(86.87±4.82)mm Hg lower than that of the control group(95.77±4.53)mm Hg.There was a difference between the groups(t=9.6088,P=0.0001).(2)The total effective rate of the study group was 90.20%higher than that of the control group(87.80%),and the comparison between groups(χ^(2)=13.4211,P=0.0002).(3)The adverse reaction rate of the study group was 5.88%lower than that of the control group(23.53%),and there was a difference between the groups(χ^(2)=14.4947,P=0.0001).Conclusion For the patients with essential hypertension,valsartan and nifedipine sustained release were performed.Tablet therapy can improve the patient's therapeutic effect,improve blood pressure,and is safer to use,less adverse reactions,and worthy of clinical promotion and application.