同剂量不同疗程静脉滴注丙种球蛋白治疗川崎病患者的疗效比较

Comparison of the Curative Effect of Intravenous Gamma Globulin in Different doSes of Treatment for Kawasaki Disease

目的比较川崎病患儿采取同剂量不同疗程静脉注射丙种球蛋白的治疗价值。方法纳入我院2018年1月至2020年12月收治的27例川崎病患儿,按照静脉丙种球蛋白不同给药方式分为Ⅰ组(16例)和Ⅱ组(11例),Ⅰ组给药剂量为2 g/kg,在1 d内滴注完,Ⅱ组给药剂量为每日1 g/kg,连用2 d,回顾性比较两组血液高凝状态及疗效。结果两组治疗前凝血活化酶时间(APTT)、血小板(PLT)、血沉(ESR)、D二聚体(D-D)比较,差异无统计学意义(P>0.05);治疗后,Ⅱ组APTT长于Ⅰ组,PLT、ESR、D-D高于Ⅰ组,差异有统计学意义(P<0.05)。Ⅰ组总有效率为100.0%,高于Ⅱ组的90.9%,差异有统计学意义(P<0.05)。结论川崎病患儿在采取单剂量丙种球蛋白治疗时的疗效确切,可显著改善血液高凝状态,应用价值显著。

Objective To study the value of intravenous gamma globulin administration with the same dose and different courses(or methods of use)in children with Kawasaki disease.Methods A total of 29 children with Kawasaki disease admitted to our hospital from January 2018 to December 2020 were divided into groupⅠ(17 cases)and groupⅡ(12 cases)according to different intravenous gamma globulin administration methods.GroupⅠwas given up 2 g/kg within 1 day,and groupⅡwas given 1 g/kg daily for 2 days.The hypercoagulability status and efficacy of the two groups were retrospectively compared.Results There were no statistically significant differences in coagulation activation enzyme time(APTT),platelet(PLT),erythrocyte sedimentation rate(ESR)and D-dimer(D-D)between the two groups before treatment(P>0.05).After treatment,APTT of groupⅡwas longer than groupⅠ,PLT,ESR,and D-D were higher than groupⅠ,the difference was statistically significant(P<0.05).The total effective rate of groupⅠwas 100.0%,which was higher than that of groupⅡ(90.9%),with significant difference between the two groups(P<0.05).Conclusion Single dose of gamma globulin in children with Kawasaki disease has a definite curative effect,which can significantly improve the hypercoagulable state of blood,so it has application value.