氨氯地平结合阿托伐他汀钙片治疗高血压合并冠心病患者的有效性

Efficacy of Amlodipine Combined with Atorvastatin Calcium Tablets in the Treatment of Hypertension Complicated with Coronary Heart Disease

目的探讨氨氯地平结合阿托伐他汀钙片对于治疗高血压合并冠心病患者的有效性。方法抽取2018年6月至2019年7月来我院就诊的110例高血压合并冠心病患者作为研究对象,按照抽签方法将其分为常规组和观察组,每组55例。常规组采用口服硝苯地平控释片的方法治疗,观察组采用口服氨氯地平和阿托伐他汀钙片联合用药的方法治疗。对比两组患者用药3个疗程后的血压情况、每周心绞痛发作频次、每次心绞痛发作持续时间及用药后不良反应。结果治疗3个疗程后,常规组患者的收缩压为130.24~141.35 mm Hg,平均(133.58±4.66)mm Hg,舒张压为90.25~96.37 mm Hg,平均(90.33±4.56)mm Hg,心绞痛发作次数为(5.27±2.34)次/周,持续时间为(4.03±2.21)min/次,用药期间不良反应发生率为29.09%,观察组收缩压为123.35~131.34 mm Hg,平均(124.37±5.45)mm Hg,舒张压为82.37~89.46 mm Hg,平均(83.25±4.25)mm Hg,心绞痛发作次数为(2.46±1.02)次/周,持续时间为(2.25±1.33)min/次,用药期间不良反应发生率为10.91%,以上数据组间比较差异均有统计学意义(P<0.05)。结论对于高血压合并冠心病的患者采用氨氯地平结合阿托伐他汀钙片的治疗方法获得的效果更好,不良反应更少。

Objective To explore the effectiveness of amlodipine combined with atorvastatin calcium tablets in treating patients with hypertension and coronary heart disease.Methods A total of 110 patients with hypertension and coronary heart disease who came to our hospital from June 2018 to July 2019 were selected as the research objects,and they were divided into routine group and observation group according to the method of drawing lots.The routine group was treated with nifedipine controlled-release tablets,while the observation group was treated with amlodipine and atorvastatin calcium tablets.The blood pressure,weekly angina attack frequency,duration of each angina attack and adverse reactions after medication were compared between the two groups.Results After three courses of treatment,the blood pressure of routine patients was measured:systolic blood pressure was 130.24~141.35 mm Hg,average(133.58±4.66)mm Hg,diastolic blood pressure was 90.25-96.37 mm Hg,average(90.33±4.56)mm Hg,the frequency and duration of angina pectoris were(5.27±2.34)times/week and(4.03±2.21)min/time,the adverse reaction rate was 29.09%.In the observation group,blood pressure was measured after three courses of treatment:systolic blood pressure was 123.35-131.34 mm Hg,with an average of(124.37±5.45)mm Hg,and diastolic blood pressure was 82.37-89.46 mm Hg,with an average of(83.25±4.25)mm Hg,the attack frequency of angina pectoris was(2.46±1.02)times/week and the duration was(2.25±1.33)min/time,the adverse reaction rate was 10.91%,all of which had statistical significance(P<0.05).Conclusion Amlodipine combined with atorvastatin calcium tablets has better effect and less side effects for patients with hypertension complicated with coronary heart disease.