保妇康栓联合辛复宁治疗人乳头瘤病毒感染效果及作用机制

Efficacy and mechanism of baofukang suppository combined with xinfuning for treating women with humanpapilloma virus infection

目的:观察保妇康栓联合辛复宁治疗人乳头瘤病毒(HPV)感染疗效并探究其作用机制。方法:观察对象来自于2018年7月—2020年7月本院门诊就诊的HPV感染患者218例,采用随机数字表法分组,对照组109例用辛复宁治疗,观察组109例在对照组治疗基础上加用保妇康栓,观察两组用药前后免疫功能[T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、Foxp3+Tregs数目、免疫球蛋白(IgA、IgG、IgM)]、炎症指标[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-2(IL-2)]改变,统计HPV转阴率,评估临床疗效及安全性,随访6个月统计复发率。结果:用药后,两组T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、Foxp3+Tregs均高于用药前且观察组高于对照组,两组免疫球蛋白(IgA、IgG、IgM)均高于用药前且观察组高于对照组,两组TNF-α、IL-6、IL-2低于用药前且观察组低于对照组(均P<0.05)。观察组HPV转阴率(93.6%)、总有效率(95.4%)高于对照组(82.6%、87.2%)(P<0.05)。不良反应率观察组(7.3%)与对照组(6.4%)无差异(P=0.982)。随访6个月观察组复发率(1.8%)低于对照组(9.2%)(P=0.023)。结论:保妇康栓联合辛复宁治疗HPV感染能调节免疫功能,减轻炎症反应,疗效显著,用药安全且复发率低。作用机制可能与调节免疫、减轻炎症反应有关。

Objective:To observe the efficacy and mechanism of baofukang suppository combined with xinfuning for treating women with humanpapilloma virus(HPV)infection.Methods:218 women with HPV infection were selected as subjects and were divided in two groups by random number table method from July 2018 to July 2020.109 women in the control group were treated with xinfuning,and 109 women in the observation group were treated with baofukang suppository combined with xinfuning.The immune function[the number of T lymphocyte subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))and Foxp3+Tregs,and the levels of immunoglobulins(IgA,IgG,IgM)],the levels changes of inflammation indicators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-2(IL-2)]of the women in the two groups were observed.The HPV conversion rate of the women was statistics analyzed.The clinical efficacy and safety of these women were evaluated,and their recurrence rate was followed up for 6 months.Result:After treatment,the numbers of T lymphocyte subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))and Foxp3+Tregs,and the levels of immunoglobulin(IgA,IgG,IgM)of the women in the two groups had increased significantly,and which of the women in the observation group were significant higher than those of the women in the control group.The levels of TNF-α,IL-6 and IL-2 of the women in the two groups had decreased significantly,and which of the women in the observation group were significant lower than those of the women in the control group(all P<0.05).The HPV negative conversion rate(93.6%)and total effective rate(95.4%)of the women in the observation group were significant higher than those(82.6%and 87.2%)of the women in the control group(P<0.05).There was no significant difference in the rate of adverse reactions(7.3%vs.6.4%)of the women between the two groups(P=0.982).The recurrence rate(1.8%)of the women in the observation group was significant lower than that(9.2%)of the women in the control group(P=0.023).Conclusion:Baofukang suppository combined with xinfuning for treating the women with HPV infection can regulate their immune function and reduce their inflammation reaction,which has significant curative effect,good safety of medication,and low recurrence rate,and which mechanism may be related to the regulation of immunity and the reduction of inflammatory response.