生育指数评分联合血清Resistin诊断子宫内膜异位症合并不孕症价值

Value of the score of endometriosis fertility index and the serum Resistin level for diagnosing endometriosis complicated with infertility

目的:探究子宫内膜异位症生育指数(EFI)评分、血清抵抗素(Resistin)对子宫内膜异位症合并不孕症诊断价值。方法:选取2018年6月—2020年6月本院收治的子宫内膜异位症患者84例(内膜异位组)、合并不孕症患者47例(合并不孕组),健康女性53例(对照组)。对3组行EFI评分和血清Resistin检测,分析两指标对子宫内膜异位症合并不孕症诊断价值。结果:对照组、内膜异位组和合并不孕组EFI评分依次降低、血清Resistin水平依次升高(P<0.05)。ROC曲线分析,EFI评分曲线下面积(AUC)、敏感度和特异度分别为0.754、0.727、0.792,血清Resistin AUC、敏感度和特异度分别为0.805、0.845、0.736,两者联合检测的AUC、敏感度和特异度(0.886、0.864、0.849),联合检测高于单项检测(P<0.05),与临床诊断的金标准一致性较好(Kappa=0.726),其灵敏度、特异度、阳性预测值、阴性预测值及准确率分别为0.861、0.867、0.847、0.879和0.864。结论:EFI评分联合血清Resistin检测对子宫内膜异位症合并不孕症有一定诊断价值。

Objective:To explore the value of the score of endometriosis fertility index(EFI)and the serum Resistin level for diagnosing endometriosis complicated with infertility.Methods:84 women with endometriosis were selected in group A,47 women with endometriosis and infertility were selected in group B,and 53 healthy women were selected in group C from June 2018 to June 2020.The EFI score and serum Resistin level of the women in the three groups were detected.The value of the combination of the EFI score and serum resistin level of the women for diagnosing endometriosis complicated with infertility was analyzed.Results:The EFI score of the women in group C,group A,and group B had significantly decreased in turn,but the serum Resistin of the women in group C,group A,and group B level had significantly increased in turn(P<0.05).ROC curve analysis showed that the area under curve(AUC),the sensitivity,and the specificity of EFI score for diagnosing endometriosis complicated with infertility were 0.754,0.727,and 0.792,respectively.The AUC,the sensitivity,and the specificity of serum Resistin level for diagnosing endometriosis complicated with infertility were 0.805,0.845,and 0.736,respectively.The AUC,the sensitivity,and the specificity of EFI score combined with serum Resistin level for diagnosing endometriosis complicated with infertility were 0.886,0.864,0.849,respectively,which were significant higher than that of EFI score or serum Resistin level alone(P<0.05),and the consistency(Kappa=0.726)of which compared to the gold standard of clinical diagnosis was better.The sensitivity,the specificity,the positive predictive value,the negative predictive value,and the accuracy of the gold standard of clinical diagnosis for endometriosis complicated with infertility were 0.861,0.867,0.847,0.879,and 0.864,respectively.Conclusion:EFI score combined with serum Resistin level has some diagnostic value for endometriosis complicated with infertility.