不同剂量黄体酮软胶囊治疗无排卵型月经失调的效果研究

Effect of different doses of Progesterone soft Capsule on Anovulatory Menstruation disorder

目的研究无排卵型月经失调患者给予不同剂量黄体酮软胶囊治疗的临床疗效。方法选取60例无排卵型月经失调患者,采用随机抽样法分为对照组与试验组,每组30例。对照组采用常规剂量黄体酮软胶囊治疗,试验组采用大剂量黄体酮软胶囊治疗,对比两组临床疗效、临床症状改善时间及不良反应发生情况。结果试验组治疗总有效率为96.67%,明显高于对照组的80.00%,差异具有统计学意义(P<0.05)。试验组阴道出血时间、月经恢复正常时间及子宫内膜恢复时间均明显短于对照组,差异具有统计学意义(P<0.05)。试验组不良反应发生率为10.00%,对照组不良反应发生率为6.67%,差异无统计学意义(P>0.05)。结论大剂量黄体酮软胶囊治疗无排卵型月经失调患者疗效优于常规剂量用药,可加快改善患者临床症状,且不会增加不良反应发生率,值得临床推广与应用。

Objective To study the clinical efficacy of soft capsule progesterone in patients with anovulatory menstruation disorder.Methods 60 patients with anovulatory menstrual disorder were randomly divided into control group and experimental group,30 cases in each group.The control group was treated with conventional dose of progesterone soft capsule,and the experimental group was treated with large dose of progesterone soft capsule.The clinical efficacy,improvement time of clinical symptoms and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of experimental group was 96.67%,significantly higher than that of control group 80.00%,the difference was statistically significant(P<0.05).The time of vaginal bleeding,menstruation and endometrial recovery in the experimental group were significantly shorter than those in the control group,with statistical significance(P>0.05).The incidence of adverse reactions was 10.00%in the experimental group and 6.67%in the control group,with no statistical significance(P>0.05).Conclusion The efficacy of highdose progesterone soft capsule in the treatment of anovulatory menstrual disorder is superior to conventional dosage,which can improve the clinical symptoms of patients more quickly and will not increase the incidence of adverse reactions,which is worthy of clinical promotion and application.