6958例儿童血清25-羟基维生素D检测结果分析

Analysis of the results of serum 25-hydroxyvitamin D in 6958 children

目的探讨该地区各年龄段儿童25-羟基维生素D[25-(OH)D]分布情况。方法随机选取该院儿保科体检的6958例0~14岁儿童为研究对象,其中0~<3岁77例,3~<5岁1587例,5~<7岁1731例,5~<7岁1595例,9~<11岁1069例,11~14岁899例;男童4026例(57.86%),女童2932例(42.14%);记录来院的体检日期,按照气象部门季节划分,将体检日期在2019年3-5月的划分为春季(1662例),体检日期在2019年6-8月的划分为夏季(2795例),体检日期在2019年9-11月的划分为秋季(1289例),体检日期在2019年12月至2020年2月的划分为冬季(1212例)。采用化学发光免疫分析法检测血清中25-(OH)D水平。结果6958例0~14岁儿童25-(OH)D的缺乏率为15.90%,不足率为52.10%,充足率为32.01%。5~<7岁、7~<9岁、9~<11岁、11~14岁儿童的25-(OH)D水平低于0~<3岁、3~<5岁儿童,差异有统计学意义(P<0.05),不同年龄段的儿童25-(OH)D缺乏率、不足率和充足率差异有统计学意义(P<0.05);春季、夏季、秋季儿童25-(OH)D水平明显高于冬季,不同季节25-(OH)D缺乏率、不足率和充足率差异有统计学意义(P<0.05)。结论应加强0~14岁儿童25-(OH)D水平监测,25-(OH)D水平不足的儿童应即时补充25-(OH)D及加强户外活动。

Objective To explore the distribution of 25-hydroxyvitamin D[25-(OH)D]in children of various ages in this area.Methods A random selection of 6958 children aged 0-14 in the hospital′s children′s health checkup was selected as the research subjects.Among them,77 cases were 0-<3 years old,1587 cases were 3-<5 years old,1731 cases were 5-<7 years old,1595 cases were 5-<7 years old,1069 cases were 9-<11 years old,899 cases were 11-14 years old;4026 cases of boys(57.86%),2932 cases of girls(42.14%).The medical examination date of the hospital was recorded.According to the season of the meteorological department,the physical examination dates from March to May 2019 were divided into spring(1662 cases),the physical examination dates from June to August 2019 were divided into summer(2795 cases),the physical examination dates from September to November 2019 were divided into autumn(1289 cases),and the physical examination dates from December 2019 to February 2020 were divided into winter(1212 cases).Chemiluminescence immunoassay was used to detect the level of 25-(OH)D in serum.Results The 25-(OH)D deficiency rate of 6958 children aged 0-14 years old was 15.90%,the insufficiency rate was 52.10%,and the adequacy rate was 32.01%.The 25-(OH)D levels of children aged 5-<7 years old,7-<9 years old,9-<11 years old,and 11-14 years old were lower than 0-<3 years old,3-<5 years old,the differences were statistically significant(P<0.05),there were statistically significant differences in the 25-(OH)D deficiency rate,insufficiency rate and adequacy rate among children of different age groups(P<0.05).The 25-(OH)D levels of children in spring,summer and autumn were significantly higher than that in winter.There were statistically significant differences in the 25-(OH)D deficiency rate,insufficiency rate and adequacy rate in different seasons(P<0.05).Conclusion The monitoring of 25-(OH)D levels in children aged 0-14 years old should be strengthened.Children with insufficient 25-(OH)D levels should immediately supplement and strengthen outdoor activities.