自噬调控巨噬细胞参与构建肿瘤微环境研究进展

Advances in autophagy regulation of macrophages involved in the construction of tumor microenvironment

自噬作为细胞高度保守的胞内代谢产物及衰老、损伤细胞器的降解途径,参与维持细胞稳态。肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)是构成肿瘤微环境的关键细胞,通过极化为M2型促进肿瘤发生、发展及转移。自噬通过调控TAMs极化、代谢来参与肿瘤微环境的构建。本文就自噬调控巨噬细胞与肿瘤微环境相互作用的机制进行阐述,旨在为靶向肿瘤微环境内TAMs和肿瘤细胞自噬调控的治疗提供新的理论基础。

Autophagy is involved in maintaining cell homeostasis as a highly conserved degradation pathway of intracellular metabolite and senescent or damaged organelles.Tumor-associated macrophages(TAMs)are the key cells in the tumor microenvironment,which can promote tumorogenesis,development,and metastasis through M2 polarization.Autophagy is an important component in the construction of the tumor microenvironment by regulating TAMs polarization and metabolism.This article reviews the mechanism of autophagy regulating the interaction between macrophages and tumor microenvironment,aiming to provide new potential theoretical autophagy regulatory targets for anti-tumor therapy.