不同剂量右美托咪定在宫颈癌手术患者中的麻醉效果及安全性

Anesthetic effect and safety of different doses of dexmedetomidine in patients undergoing cervical cancer surgery

目的分析不同剂量右美托咪定在宫颈癌手术患者中的麻醉效果及安全性。方法根据手术中麻醉剂用量的不同将120例宫颈癌患者分为A组、B组和C组,各40例。麻醉诱导前15 min,分别给予A组、B组、C组患者0.3、0.5、1.0μg/kg右美托咪定。观察三组的麻醉效果及安全性。结果B组的拔管时间、苏醒时间、应答时间短于A组和C组(P<0.05);术后48 h内,三组Ramsay和VAS最高评分两两比较,差异无统计学意义(P>0.05)。C组T_(1)~T_(5)的心率、平均动脉压均低于A组与B组(P<0.05)。B组的麻醉不良反应总发生率低于A组和C组(P<0.05)。A组的瑞芬太尼及丙泊酚使用剂量均高于B组和C组(P<0.05)。结论麻醉诱导前15 min给予宫颈癌手术患者0.5μg/kg的右美托咪定可获得较好的麻醉效果,且安全性较高。

Objective To analyze the anesthetic effect and safety of different doses of dexmedetomidine in patients undergoing cervical cancer surgery.Methods A total of 120 patients with cervical cancer were divided into group A,group B and group C according to the different dosage of anesthetic during operation,with 40 cases in each group.At 15 min before anesthesia induction,patients in group A,group B and group C were given 0.3,0.5 and 1.0μg/kg dexmedetomidine respectively.The anesthetic effect and safety of the three groups were observed.Results The extubation time,recovery time and response time of the group B were shorter than those of the group A and the group C(P<0.05);within 48 h after operation,in the three groups,there were no significant differences in the highest scores of Ramsay and VAS between each two groups(P>0.05).The heart rate and mean arterial pressure from T_(1) to T_(5) in the group C were lower than those in the group A and the group B(P<0.05).The total incidence of adverse anesthetic reactions in the group B was lower than that in the group A and the group C(P<0.05).The dosages of remifentanil and propofol in the group A were higher than those in the group B and the group C(P<0.05).Conclusion At 15 min before anesthesia induction,0.5μg/kg dexmedetomidine for patients undergoing cervical cancer surgery can obtain better anesthetic effect with high safety.