心脏再同步化治疗对心律失常导致心力衰竭患者心功能、不良事件发生情况的影响

Effects of cardiac resynchronization therapy on cardiac function and occurrence of adverse events in patients with heart failure caused by arrhythmia

目的探讨心脏再同步化治疗(CRT)对心律失常导致心力衰竭患者心功能、不良事件发生情况的影响。方法将82例心律失常导致心力衰竭患者根据治疗方法的不同分为对照组(n=41,常规药物治疗)和观察组(n=41,CRT)。比较两组的治疗效果。结果治疗后1个月,两组患者的LVEF、FS均较治疗前升高,LVEDD、X线心胸比均较治疗前减小,且观察组优于对照组(P<0.05)。治疗后1个月,两组患者的心率、NT-proBNP水平均较治疗前降低,且观察组低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。观察组随访6个月内的不良事件总发生率低于对照组(P<0.05)。结论CRT应用在心律失常导致心力衰竭患者中,可促进患者心功能的改善和心率恢复,降低NT-proBNP水平,减少不良事件的发生,疗效确切。

Objective To investigate the effects of cardiac resynchronization therapy(CRT)on cardiac function and occurrence of adverse events in patients with heart failure caused by arrhythmia.Methods Eighty-two patients with heart failure caused by arrhythmia were divided into control group(n=41,conventional drugs treatment)and observation group(n=41,CRT)according to different treatment method.The therapeutic effects of the two groups were compared.Results One month after treatment,LVEF and FS of the two groups were higher than those before treatment,LVEDD and X-ray cardiothoracic ratio were lower than those before treatment,and those of the observation group were better than the control group(P<0.05).One month after treatment,the heart rate and NT-proBNP level of the two groups were lower than those before treatment,and those of the observation group were lower than the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).The total incidence of adverse events within 6 months of follow-up in the observation group was lower than that in the control group(P<0.05).Conclusion The CRT applied in patients with heart failure caused by arrhythmia can promote the improvement of cardiac function and heart rate recovery,and reduce the level of NT-proBNP and the occurrence of adverse events,with definite effect.