(Q)SAR技术在药物杂质遗传毒性评价中的应用

Application of(Q)SAR Analysis in the Genotoxic Evaluation of Drug Impurities

药物杂质遗传毒性评价遵循ICH M7指导原则,基于风险评估的原则,在药品注册时,可以采用计算机辅助的(定量)构效关系,即(Q)SAR评价方法研究杂质的致突变性。本文从基本要求、软件选择、结果解读和应用等方面,综述了(Q)SAR技术在药物杂质遗传毒性评价中的应用,以促进我国药物遗传毒性杂质的评价和控制的规范化。

The International Council for Harmonization(ICH)M7 guideline describes a hazard assessment process for impurities that have the potential to be present in a drug substance or drug product.Based on the principle of risk assessment,In the absence of adequate experimental bacterial mutagenicity data,(Q)SAR analysis may be used as a test to predict impurities’DNA reactive(mutagenic)potential.To promote the standardization of the evaluation and control of drug genotoxic impurities in China,we reviewed the basic principles of(Q)SAR analysis,the software selection,the application and the expert review of the(Q)SAR results,et al.