心脏淀粉样变实验室检查研究进展

Laboratory examination of cardiac amyloidosis

心脏淀粉样变是一类由于前体蛋白发生异常β折叠形成的淀粉样纤维不断浸润损伤心肌细胞,最终导致以心肌舒张功能受损为主要临床表现的心脏疾病。该病临床表现复杂,诊断困难,治疗方法局限,预后差。近年,随着新检测技术的不断发展,心脏淀粉样变的诊断率明显提高。为提高对心脏淀粉样变的认识,推进该病的规范化诊治,本文就心脏淀粉样变的发病机制和实验室检查的研究进展作一综述。

Cardiac amyloidosis is a type of heart disease with the main clinical manifestation of impaired myocardial diastolic function induced by continuous infiltration and damage of myocardial cells by amyloid fibrils formed by abnormal β-sheets of precursor protein.Since the clinical manifestations of the disease are complex and diverse, the diagnosis is difficult, the treatment methods are limited, and the prognosis is poor.In recent years, with the adoption of new detection techniques, the diagnostic rate of cardiac amyloidosis has increased significantly.This paper reviews the research progress of the pathogenesis and laboratory examinations of cardiac amyloidosis to deepen the understanding of cardiac amyloidosis and promote the standardization of diagnosis and treatment of cardiac amyloidosis.