摘要
Dear Editor,Mucin 1(MUC1)contains N-and C-subunit that forms a heterodimer on the apical surface of luminal epithelial cells.Nevertheless,MUC1 is aberrantly overexpressed in various cancers,such as breast cancer,lung cancer,and prostatic cancer,which critically contributes to tumorigenesis and poor clinical outcomes.1 Several strategies have been developed for targeted-inhibition of MUC1 including vaccines,monoclonal antibodies(MAb),and polypeptide.
基金
This work was supported by National Natural Science Foundation of China(grant numbers 82073111 and 81874197)to L.H.and Chinese Universities Scientific Fund
CAMS Innovation Fund for Medical Sciences(2019-I2M-5-051)to G.C.
