基于中西医临床病证特点的慢性支气管炎动物模型分析

Analysis of Chronic Bronchitis Animal Model Based on the Characteristics of Clinical Symptoms in Chinese and Western Medicine

基于对现有的慢性支气管炎动物模型应用的文章加以整理、归类、分析,综合其特点,发现慢性支气管炎动物模型中使用最多的是烟熏法、脂多糖(LPS)法等;动物模型建立操作简便,成模率高,其在现代医学病理上较为吻合,与中医病证特点符合度较低。通过归纳动物模型的优缺点,发现未来动物模型的建立,需更贴合临床疾病的发生特点,从病因病机上也应与中医病证相结合。

Literatures of existing animal models with chronic bronchitis were analyzed, categorized, and summarized, the results showed that smoking, lipopolysaccharide(LPS), etc. were frequently used to establish the animal models of chronic bronchitis. The establishment methods of these animal models are easy to operate, and have the high successful rate. The models and the disease are consistent in modern pathology, while they are low conformity in the characteristics of traditional Chinese medicine. By summarizing the advantages and disadvantages of animal models, it is found that the animal models established in the future need to be more suitable for the characteristics of clinical diseases, and the etiology and pathogenesis in traditional Chinese medicine should also be considered when the models are to be established.