卡前列素氨丁三醇、米索前列醇和缩宫素三联方案治疗产后出血的临床效果

The clinical effect of carboprost tromethamine, misoprostol and oxytocintriple regimen in the treatment of postpartum hemorrhage

目的:探究卡前列素氨丁三醇、米索前列醇和缩宫素三联方案治疗产后出血的临床疗效及不良反应,为临床医师选择合理用药方案提供参考。方法:选取2019年1月1日至2020年12月31日康平县人民医院诊疗的142例产后出血患者作为研究对象,依据随机数字表法,将研究对象分为两组,对照组和观察组(每组病例数为71例),对照组采用米索前列醇和缩宫素联合用药方案治疗,观察组采用卡前列素氨丁三醇、米索前列醇和缩宫素三联方案治疗,对比两组的临床治疗总有效率、相关临床指标(出血持续时间、出血量及不同时间节点的血红蛋白水平)及用药不良反应发生率。结果:观察组的临床治疗总有效率高于对照组,差异显著(P<0.05)。观察组的出血持续时间短于对照组,出血量少于对照组,差异有统计学意义(P<0.05)。用药前,两组患者的血红蛋白水平比较,无明显差异(P>0.05);用药2h、用药24h,观察组患者的血红蛋白值均高于对照组,差异显著(P<0.05)。两组患者的用药不良反应发生率比较,无统计学差异(P>0.05)。结论:卡前列素氨丁三醇、米索前列醇和缩宫素三联方案治疗产后出血的临床效果显著,可有效改善患者出血状况,维持血红蛋白水平,促进康复,可在临床上应用。

Objective:To explore the clinical efficacy and adverse reactions of carboprost tromethamine,misoprostol and oxytocin triple regimen in the treatment of postpartum hemorrhage,so as to provide reference for clinicians to choose rational drug use.Methods:A total of 142 cases with postpartum hemorrhage in Kangping People's Hospital from January 1,2019 to December 31,2020 were selected as the research subjects.According to the random number table method,the research subjects were divided into two groups:control group and observation group(71 cases in each group).The control group was treated with misoprostol and oxytocin combination regimen,while the observation group was treated with carboprost tromethamine,misoprostol and oxytocin triple regimen.The total effective rate,related clinical indicators(bleeding duration,bleeding volume and hemoglobin level at different time nodes)and the incidence of adverse drug reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).The duration of bleeding in the observation group was shorter than that in the control group,the amount of bleeding was less than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in hemoglobin level between the two groups(P>0.05);After treatment for 2 hours and 24 hours,The hemoglobin values of patients in the observation group were all higher than those of the control group,with significant differences(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:The clinical effect of carboprost tromethamine,misoprostol and oxytocin triple regimen in the treatment of postpartum hemorrhage is significant,which can effectively improve the bleeding status of patients,maintenance of hemoglobin levels,promote rehabilitation,and can be popularized in clinical application.