新生儿缺血缺氧性脑病应用神经节苷脂联用还原型谷胱甘肽治疗对症状改善的作用

Effect of ganglioside combined with reduced glutathione on symptoms of neonatal hypoxic ischemic encephalopathy

目的:研究在新生儿缺血缺氧性脑病(HIE)患儿采取还原型谷胱甘肽与神经节苷脂联合治疗的价值。方法:本院于2018年1月至2019年11月纳入82例HIE患儿开展研究。依据住院号尾数单双号随机选出41例予以神经节苷脂+胞二磷胆碱治疗(A组),另外41例实施神经节苷脂+还原型谷胱甘肽治疗(B组),评估两组疗效。结果:B组患儿治疗后总有效率,NBNA及Gesell评分,肌张力消失、惊厥消失及意识障碍消失时长均优于A组(P<0.05)。结论:还原型谷胱甘肽与神经节苷脂联合用药方案在新生儿HIE患儿治疗中合理应用,可显著提升临床疗效,有利于肌张力异常、惊厥及意识障碍等症状改善,还能促进患儿NBNA及Gesell评分提升,建议临床应用。

Objective:To study the value of combined treatment of reduced glutathione and ganglioside in neonatal hypoxic ischemic encephalopathy(HIE).Methods:From January 2018 to November 2019,82 children with HIE were enrolled in the study.According to the odd or even number of inpatient number,41 cases were randomly selected to be treated with ganglioside+citicoline(group A),and the other 41 cases were treated with ganglioside+reduced glutathione(group B).Results:The total effective rate,NBNA and Gesell scores,duration of disappearance of muscle tension,convulsion and disturbance of consciousness in group B were better than those in group A(P<0.05).Conclusion:The rational application of reduced glutathione and ganglioside in the treatment of neonatal HIE can significantly improve the clinical efficacy,improve the symptoms of dystonia,convulsion and disturbance of consciousness,and promote the NBNA and Gesell scores of children.It is suggested that the clinical application should be promoted.