姜黄素及其纳米制剂在中枢神经系统疾病治疗中的应用

Application of Curcumin and Its Nanoparticles in the Treatment of Central Nervous System Diseases

姜黄素是一种从姜黄属植物的根茎中提取出来的疏水性多酚,具有抗癌、抗炎、抗氧化等多种药理作用,可以改善癌症、糖尿病和脑外伤等多种疾病症状。随着研究的深入,发现其具有较好的抗炎和神经保护作用。已有机制证明姜黄素在治疗神经系统疾病方面有良好的潜力。但是溶解性差、稳定性低、体内清除率快和血脑屏障(blood brain barrier,BBB)渗透性差等缺点限制了其临床应用。近年来,基于纳米颗粒的药物递送系统有效地改善了姜黄素的水溶性和生物利用度。在该文综述中,姜黄素及其纳米制剂的作用及其可能的作用机制已在各种与中枢神经系统(central nervous system,CNS)相关的疾病中阐明,包括阿尔茨海默氏病、帕金森氏病、多发性硬化症、肌萎缩性侧索硬化症和胶质母细胞瘤等。

Curcumin is a kind of hydrophobic polyphenol extracted from the rhizome of Curcuma.It has many pharmacological effects,such as anticancer,antiinflammatory and antioxidation.It can improve the symptoms of cancer,diabetes and brain injury.With the development of research,it has been found that it has good antiinflammatory and neuroprotective effects.Curcumin has been proved to have good potential in the treatment of nervous system diseases.However,poor solubility,low stability,rapid clearance rate in vivo and poor permeability of bloodbrain barrier(BBB)limit its clinical application.In recent years,nanoparticles based drug delivery systems have effectively improved the water solubility and bioavailability of Curcumin.In this review,effects and possible mechanisms of Curcumin and its nanoparticles have been elucidated in a variety of central nervous system(CNS)related diseases,including Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,amyotrophic lateral sclerosis and glioblastoma,etc.