结直肠癌患者口服化疗用药依从性与疾病感知的相关性研究

Colorectal Cancer Patients’s Compliance to Orally Administering Chemotherapy Drugs and Their Recognition about Disease:A Relativity Study

为探讨结直肠癌患者口服化疗用药依从性与疾病感知的相关性,选择100例结直肠癌口服药物化疗者进行研究,分别于化疗早期(1个疗程后)、中期(4个疗程后)、晚期(8个疗程后)应用Morisky药物依从性量表和简易版疾病感知问卷(中文版)对患者用药依从性和疾病感知情况进行评估,分析它们之间的相关性。结果显示,化疗早期、中期、晚期患者用药依从性评分分别为(7.29±1.18)分、(6.89±1.38)分和(6.82±1.12)分,疾病感知评分分别为(40.14±9.45)分、(39.87±8.62)分和(37.04±6.85)分。化疗不同时期患者用药依从性与其疾病感知水平均呈负相关(r=-0.205,P <0.05;r=-0.277,P <0.05;r=-0.276,P <0.05)。结果表明,结直肠癌口服药物化疗者疾病感知水平越高,用药依从性越差。临床工作中,应做好健康宣教工作,引导患者正确认知疾病,提高口服化疗用药依从性。

This study was to explore the relativity of colorectal cancer patients’ compliance to orally administering chemotherapy drugs and their recognition about disease,enrolled 110 colorectal cancer patients being orally administering chemotherapy drugs into this research:by using Morisky drug-compliance scale and questionnaire about recognition on disease(Chinese edition)to evaluate their compliance and recognition status at chemotherapy early stage(after 1 treatment course),at chemotherapy mid-stage(after 4 treatment courses),and at chemotherapy late stage(after 8 treatment courses),then the relativity between both was analysed.As results,at early,mid-and late stage,their compliance ratings were respectively(7.29±1.18)points,(6.89±13.8)points,and(6.82±1.12)points,while,the ratings on recognition respectively,(40.14±9.45)points,(39.87±8.62)points,and(37.04±6.83)points;at difference chemotherapy stage the relativity of both showed negative relation(r=-0.205,P <0.05;r=-0.277,P <0.05;r=-0.276,P<0.05).Results show that more higher the recognition is,more poor the compliance,therefore,it should be better taking health teaching to patients,and guiding them rightly recognize disease,and enhancing their compliance to orally administering chemotherapy drugs.