组蛋白降解调控机制的研究进展

Research Progresses on the Regulatory Mechanism of Histone Degradation

组蛋白是染色质的重要组成部分,其含量的高低显著影响着染色质高级结构的形成、基因表达、DNA复制等重要生命活动。蛋白质降解是组蛋白含量调控的重要机制,大量研究表明,组蛋白的降解与其氨基酸残基的修饰方式有着密不可分的联系。此外,组蛋白的降解与其泛素化、乙酰化等共价修饰密切相关。该文以组蛋白氨基酸残基翻译后修饰(PTM)为关注点,重点介绍组蛋白降解与氨基酸残基修饰之间的相互关系,并对该领域的研究进展进行综述。

Histone is an important component of chromatin,and its content significantly affects the formation of higher structure,gene expression,DNA replication and other important life activities of chromatin.Protein degradation is an important mechanism for the regulation of histone content.Numerous studies have shown that the degradation of histone is closely related to the modification of its amino acid residues.Besides,histone degradation is closely correlated with its covalent modifications such as ubiquitination and acetylation.This review focuses on PTM (post-translational modification) of histone amino acid residues,introduces the relationship between histone degradation and modification of amino acid residues,and reviews the recent advances in this field.