Dicer:肿瘤中的两面性

Dicer:the Dual Role in Tumors

Dicer是一种Ⅲ型核糖核酸内切酶,在RNA干扰(RNAi)途径中发挥重要作用。越来越多的证据表明,Dicer除产生小RNA外,还参与了染色质结构重塑、异染色质形成和凋亡DNA降解。此外,Dicer的转录和蛋白水平须严格控制,其微小变化经过累积会引发许多病理过程,甚至诱发癌变。Dicer既能作为肿瘤抑制因子起作用,又能促使肿瘤发生发展。因此,Dicer作用机制的阐明,对于肿瘤发生机制的揭示和肿瘤的靶向治疗具有重要意义。

Dicer is a type Ⅲ endonuclease,which plays an important role in RNAi (RNA interference) pathway.Emerging evidence demonstrates that Dicer is involved in chromatin remodeling,heterochromatin formation and apoptotic DNA degradation in addition to small RNA production.In addition,Dicer’s transcription and protein levels should be strictly controlled,because even small changes in Dicer accumulation can lead to various pathological processes,such as carcinogenesis.Dicer can not only act as a tumor suppressor,but also promote the occurrence and development of tumor.Therefore,the elucidation of Dicer’s mechanism of action is of great significance for revealing the mechanism of tumorigenesis and tumor targeted therapy.