保留盆腔自主神经宫颈癌根治术对患者的远期疗效meta分析

Meta-analysis of the long-term curative effect of nerve-preserving radical hysterectomy

目的通过meta分析比较保留盆腔自主神经宫颈癌根治术(NSRH)和传统根治性子宫切除术(RH)的远期盆腔器官功能障碍发生率和生存结局。方法计算机检索PubMed等数据库,采用Cochrane协作网提供的RevMan5.3软件和Stata16软件进行统计学分析。结果最终纳入研究21篇,总样本量3102例,其中NSRH组1404例,RH组1698例。NSRH术后患者膀胱、直肠和性功能障碍的发生率低于RH,两者的总生存率和无病生存率无显著差异。结论NSRH能维持RH的有效性,并可降低盆腔器官功能障碍的发生率,但是由于纳入的研究属于非随机对照试验,其安全性和有效性仍需大样本随机双盲对照试验进一步验证。

Objective:To compare the long-term pelvic organ function of nerve-sparing radical hysterectomy(NSRH)and traditional radical hysterectomy(RH)by meta-analysis obstacle incidence and survival outcome.Methods:The computer searched PubMed and other databases,using RevMan5.3 software and Stata16 software provided by Cochrane Collaboration Network for statistical analysis.Results:A total of 21 studies were finally included,with a total sample size of 3102 cases,including 1404 cases in the NSRH group and 1698 cases in the RH group.The incidence of bladder,rectum and sexual dysfunction in patients after NSRH was lower than that of RH,and there was no significant difference between the two in overall survival rate and disease-free survival rate.Conclusion:NSRH can maintain the effectiveness of RH,and can reduce the incidence of pelvic organ dysfunction.However,the included studies are non-randomized controlled trials,their safety and effectiveness still need to be further verified by a large randomized double-blind controlled trial.