穴位埋线通过影响血胰高血糖素样肽-1(GLP-1)浓度治疗单纯性肥胖症(胃热滞脾)疗效观察

Clinical Observation of Acupoint Catgut Embedding in Treatment of Simple Obesity(Stomach Heat and Spleen Stagnation Syndrome) by Influencing Blood GLP-1 Concentration

目的观察穴位埋线通过影响胃热滞脾单纯性肥胖症患者血胰高血糖素样肽-1(GLP-1)浓度来延迟胃排空速度,抑制进食欲望,减少食物摄入,降低脂类物质的吸收,减轻其体质量。方法选取湖南中医药大学第三附属医院2018年9月-2020年1月收治的胃热滞脾型单纯性肥胖患者60例,按照随机数字表法分为观察组与对照组各30例,观察组采用穴位埋线结治疗,对照组采用常规针刺治疗。观察两组治疗前后血GLP-1浓度、体质量指数(BMI)的变化情况。结果治疗前两组的血GLP-1浓度、BMI比较,差异无统计学意义(P>0.05)。治疗3个疗程后,总有效率观察组高于对照组(P<0.05);观察组GLP-1浓度明显高于治疗前,且高于对照组(P<0.05);观察组的BMI明显低于治疗前,且低于对照组(P<0.05)。结论穴位埋线可通过调整血GLP-1浓度来抑制胃热滞脾型单纯性肥胖症患者的胃排空速度、摄食欲望及进食次数,降低BMI。

Objective To observe the effect of acupoint catgut embedding on the blood concentration of glucogan like peptide-1(GLP-1) in patients with simple obesity with stomach heat and spleen stagnation syndrome to delay gastric emptying speed, inhibit the desire to eat, and reduce food intake, the absorption of lipids and their weight.Methods A total of 60 cases of simple obesity with stomach heat and spleen stagnation syndrome admitted to the Third Affiliated Hospital of Hunan University of Chinese Medicine from September 2018 to January 2020 were selected and divided into the experimental group and the control group according to the random number table method, with 30 cases in each group. The experimental group was treated with acupoint catgut embedding therapy, while the control group was treated with conventional acupuncture therapy. Changes of GLP-1 concentration and body mass index(BMI) were observed before and after treatment in the two groups.Results There was no significant difference in GLP-1 concentration or BMI between the two groups before treatment(P>0.05). After 3 courses of treatment, the total effective rate of the experimental group was higher than that of the control group was statistically significant(P<0.05). The GLP-1 concentration in the experimental group was significantly higher than that in the control group before treatment, and the difference was statistically significant(P<0.05). The BMI of the experimental group was significantly lower than that of the control group before treatment and the difference was statistically significant(P<0.05).Conclusion Acupoint catgut embedding can suppress gastric emptying speed, feeding desire and frequency of food and reduce body mass index(BMI) in patients with simple obesity with stomach heat and spleen stagnation syndrome by adjusting blood GLP-1 concentration.