通络益肾方联合针灸治疗腰椎间盘突出症对清除氧自由基能力分析

Analysis of Oxygen Free Radical Scavenging Ability of Patients with Lumbar Intervertebral Disc Herniation Treated with Tongluo Yishen Recipe(通络益肾方)Combined with Acupuncture and Moxibustion

目的分析自拟通络益肾方联合针灸治疗腰椎间盘突出症对患者清除氧自由基能力。方法选取医院2017年2月—2019年2月收治的腰椎间盘突出症患者100例,采用随机数字法分为两组。对照组给予常规综合治疗,观察组给予自拟通络益肾方联合针灸辅助治疗,分析两组患者治疗后的临床效果。结果观察组总有效率(94.00%,47/50)高于对照组(78.00%,39/50),差异具有统计学意义(P<0.05)。两组治疗前Fas/APO-1、白细胞介素-17(IL-17)、血管内皮细胞生长因子(VEGF)、5-羟色胺(5-HT)、氧化应激水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后超氧化物歧化酶(SOD)水平高于对照组,Fas/APO-1、IL-17、VEGF、5-HT、丙二醛(MDA)水平低于对照组(P<0.05)。两组治疗前视觉模拟(VAS)评分、Oswestry功能障碍指数问卷表(ODI)评分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后VAS评分(0.93±0.30)分、ODI评分(9.32±1.25)分低于对照组(P<0.05)。结论自拟通络益肾方联合针灸治疗腰椎间盘突出症可促进氧自由基的清除,调节Fas/APO-1、IL-17、VEGF、5-HT的表达水平,减轻疼痛,提高疗效。

Objective To analyze the ability of scavenging oxygen free radicals in patients with lumbar disc protrusion treated with Tongluo Yishen Recipe(通络益肾方) combined with acupuncture and moxibustion. Methods A total of 100 cases of lumbar disc herniation were selected from February 2017 to February 2019, and two groups were randomly divided into two groups. In the control group, the routine comprehensive treatment was given, and the observation group was given a combination of the self-made Tongluo Yishen Recipe and the acupuncture-assisted treatment, and the clinical effect after the treatment of the two patients was analyzed. Results The total effective rate in the observation group(94.00%,47/50) was significantly higher than that in the control group(78.00%,39/50). There was no significant difference in Fas/APO-1, IL-17, vascular endothelial growth factor(VEGF), 5-hydroxytryptamine(5-HT) or oxidative stress between the two groups before treatment(P>0.05). After treatment, the level of SOD in the observation group was higher than that in the control group, and the levels of malondialdehyde(MDA), Fas/APO-1,IL-17,VEGF and 5-HT in the observation group were higher than those in the control group. There was no significant difference in visual analog(VAS) score or Oswestry dysfunction index questionnaire(ODI) score between the two groups before treatment(P>0.05). After treatment, the VAS score and ODI score in the observation group were(0.93 ±0.30) points and(9.32±1.25) points, respectively, which were lower than those in the control group(P<0.05). Conclusion Self-made Tongluo Yishen Recipe combined with acupuncture and moxibustion can promote the scavenging of oxygen free radicals, regulate the expressions of Fas/APO-1,IL-17,VEGF and 5-HT, relieve pain and improve the curative effect.