中医药调节肠道菌群防治溃疡性结肠炎的研究进展

Research Advances on Regulation of Intestinal Flora by Traditional Chinese Medicine in Prevention and Treatment of Ulcerative Colitis

溃疡性结肠炎(ulcerative colitis, UC)是一种慢性和复发性肠道炎症性疾病,其发病机制尚不明确。肠道菌群是细菌,真菌和病毒的动态群落,介导黏膜稳态和生理。微生物组的失衡和对肠道细菌的异常免疫反应会破坏体内平衡,并与人类的炎症性肠病和小鼠的结肠炎有关。目前,中医药治疗溃疡性结肠炎疗效显著,并体现出多靶点、多机制、多途径等优势。系统阐述中医药对溃疡性结肠炎肠道菌群紊乱的调节作用以探讨新的可能机制,为该病治疗提供新的治疗策略和思路。

Ulcerative colitis is a chronic and recurrent intestinal inflammatory disease, and its pathogenesis is still unclear. The intestinal flora is a dynamic community of bacteria, fungi and viruses that mediate mucosal homeostasis and physiology. Imbalances in the microbiome and abnormal immune response to gut bacteria disrupt homeostasis and have been linked to inflammatory bowel disease in humans and colitis in mice. At present, the treatment of ulcerative colitis by traditional Chinese medicine has a significant effect, and it has demonstrated the advantages of multiple targets, multiple mechanisms and multiple pathways. In this paper, the role of traditional Chinese medicine in regulating intestinal flora disorders of ulcerative colitis would be systematically explained to explore new possible mechanisms and provide new therapeutic strategy and ideas for the treatment of ulcerative colitis.