微生态制剂辅助治疗喘息性支气管炎的疗效及对患儿免疫功能的影响

Efficacy of microbiological agent in the adjuvant treatment of asthmatic bronchitis and the effect on immune function of children

目的探究微生态制剂辅助治疗喘息性支气管炎的临床疗效及对患儿免疫功能的影响。方法回顾性分析2019年5月至2020年6月在福建医科大学附属宁德市闽东医院儿科就诊的108例喘息性支气管炎患儿的临床资料,根据其治疗方案不同进行分组,常规治疗组(n=55)采用常规方法对症治疗,益生菌治疗组(n=53)在常规方法治疗的基础上加用微生态制剂治疗。对两组的治疗总有效率、治疗前后患儿免疫功能指标变化以及喘息性支气管炎复发情况进行观察。结果益生菌治疗组的治疗总有效率96.23%,显著高于常规治疗组的80.00%(P<0.05)。治疗前,两组的IgA、IgE、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05),经治疗后两组的IgA、CD4^(+)、CD4^(+)/CD8^(+)指标均高于治疗前,IgE、CD8^(+)指标低于治疗前,且益生菌治疗组的IgA、CD4^(+)、CD4^(+)/CD8^(+)水平显著高于常规治疗组,IgE、CD8^(+)明显低于常规治疗组(P<0.05)。随访3~6个月,益生菌治疗组患儿喘息复发率5.66%,明显低于常规治疗组23.64%(P<0.05)。结论微生态制剂辅助治疗喘息性支气管炎能够提高疗效,改善患儿的免疫功能,利于减少喘息复发,值得推广应用。

Objective T o investigate the clinical efficacy of microbiological agent in the adjuvant treatment of asthmatic bronchitis and the effect on the immune function of children.Methods The clinical data of 108 children with asthmatic bronchitis who attended the Department of Pediatrics of Mindong Hospital Affiliated to Fujian Medical University from May 2019 to June 2020 were retrospectively analyzed.These children were grouped into two groups according to the difference of treatment schemes,the conventional treatment group(n=55)was treated symptomatically by conventional methods,while the probiotic treatment group(n=53)was treated by conventional methods with the addition of microbiological agent.The total effective rate of treatment,changes in immune function indicators and recurrence of asthmatic bronchitis in the two groups were observed.Results The total effective rate of treatment of the probiotic treatment group was 96.23%,which was significantly higher than that of the conventional treatment group(80.00%)(P<0.05).Before treatment,there were no statistically significant differences between the two groups in immunoglobulin A(IgA),immunoglobulin E(IgE),cluster of differentiation 4 positive(CD4^(+)),cluster of differentiation 8 positive(CD8^(+)),and CD4^(+)/CD8^(+)levels(P>0.05).After treatment,the IgA,CD4^(+),CD4^(+)/CD8^(+)levels of both groups were higher than those before treatment,and IgE and CD8^(+)levels were lower than those before treatment.Meanwhile,the IgA,CD4^(+),CD4^(+)/CD8^(+)levels in the probiotic treatment group were significantly higher than those in the conventional treatment group,and IgE and CD8^(+)levels were significantly lower than those in the conventional treatment group(P<0.05).During 3-6 months of follow-up,the recurrence rate of wheezing in children in the probiotic treatment group was 5.66%,which was significantly lower than that in the conventional treatment group(23.64%)(P<0.05).Conclusion In the adjuvant treatment of asthmatic bronchitis,microbiological agent can enhance the efficacy,improve the immune function of children,and reduce the recurrence of wheezing,which is worthy of promotion and application.