109例肺炎链球菌感染的临床分布及耐药性分析

Clinical distribution and drug resistance analysis of 109 cases of streptococcus pneumoniae infection

目的:探讨肺炎链球菌感染的临床分布特点及耐药性变化,为临床抗感染治疗提供依据。方法:收集某院2017年-2019年临床分离的非重复肺炎链球菌,对菌株的来源分布和药敏试验结果进行统计分析。结果:109株肺炎链球菌的临床分离患者以<5岁婴幼儿及>50岁中老年人为主,分别占18.3%、59.6%;标本种类以全血和痰为主,分别占43.1%、46.8%;检出季节以冬季最多,秋季次之;药敏结果显示肺炎链球菌对红霉素、四环素耐药性较强,对阿莫西林、泰利霉素耐药率均有一定幅度的下降(P<0.01),未检出万古霉素、利奈唑胺耐药株。结论:临床分离肺炎链球菌对于红霉素、四环素耐药率较高,对于万古霉素、利奈唑胺、莫西沙星、左氧氟沙星具有较高的敏感性,临床医生可根据此结论进行经验性的治疗。

Objective:To analyze the clinical distribution characteristics and drug resistance changes of Streptococcus pneumoniae infection,and to provide basis for clinical anti-infection treatment.Methods:Collect non-repetitive Streptococcus pneumoniae clinically isolated from 2017 to 2019,and perform statistical analysis on the source distribution of the strains and the results of drug susceptibility tests.Results:The clinically isolated patients of 109 strains of Streptococcus pneumoniae are mainly infants around 5 years old and middle-aged and elderly people around 50 years old,accounting for 18.3%and 59.6%respectively.The samples were mainly whole blood and sputum,accounting for 43.1%and 46.8%,respectively.Winter was the most detected season,followed by autumn.The results of drug sensitivity showed that Streptococcus pneumoniae had strong resistance to erythromycin and tetracycline,and the resistance rates to amoxicillin and telicycin were decreased to a certain extent(P<0.01).No vancomycin and linezolid resistant strains were detected.Conclusion:Clinically isolated Streptococcus pneumoniae is resistant to erythromycin and tetracycline,and a high sensitivity to vancomycin,linezolid,moxifloxacin and levofloxacin.Clinicians can conduct empirical treatment based on this conclusion.